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 Blood, 15 June 2004, Vol. 103, No. 12, pp. 4672-4673.
Prepublished online as a Blood First Edition Paper on January 22, 2004; DOI 10.1182/blood-2003-11-4060.

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RED CELLS
Brief report

A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia

Z. Leah Harris, Sandra R. Davis-Kaplan, Jonathan D. Gitlin, and Jerry Kaplan

From the Department of Anaesthesiology, The Johns Hopkins University School of Medicine, Baltimore, MD; Department of Pathology, University of Utah School of Medicine, Salt Lake City; and Department of Pediatrics, Washington University School of Medicine, St Louis, MO.

Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These results show the conservation of function of copper-containing proteins in eukaryotic iron metabolism. (Blood. 2004;103:4672-4673)


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