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Blood, 15 January 2004, Vol. 103, No. 2, pp. 673-675. Prepublished online as a Blood First Edition Paper on August 28, 2003; DOI 10.1182/blood-2003-04-1065. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-04-1065v1 103/2/673    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Höflich, C. Articles by Suttorp, N. Search for Related Content PubMed PubMed Citation Articles by Höflich, C. Articles by Suttorp, N. Related Collections Immunobiology Signal Transduction Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief report Naturally occurring anti–IFN- autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans Conny Höflich, Robert Sabat, Simone Rosseau, Bettina Temmesfeld, Hortense Slevogt, Wolf-Dietrich Döcke, Gerald Grütz, Christian Meisel, Elke Halle, Ulf B. Göbel, Hans-Dieter Volk, and Norbert Suttorp From the Institute for Medical Immunology, the Department of Internal Medicine, and the Institute for Microbiology, University Hospital Charité, Humboldt University, Berlin, Germany. Recently various genetic defects in immunity mediated by interferon (IFN-) have been described, including mutations in the IFN- receptor 1 (IFN-R1) and receptor 2 (IFN-R2), signal transducer and activator of transcription 1 (STAT 1), and interleukin 12 receptor 1 (IL-12R1), and IL-12 p40 genes. These mutations are associated with the occurrence of severe infections with intracellular pathogens especially nontuberculous mycobacteria and vaccine-associated bacilli Calmette-Guérin (BCG). Here we report data on a previously healthy adult patient primarily presenting with severe infections with Burkholderia cocovenenans and subsequently Mycobacterium cheloneae. We found a strong inhibitory anti–IFN- activity in the patient's plasma and identified a highaffinity neutralizing anti–IFN- autoantibody. Unfortunately, the patient died due to severe sepsis before we knew the nature of the inhibitory activity. The application of alternative therapeutic approaches such as intravenous immunoglobulin or immunoadsorption may have been beneficial in this case. Screening for neutralizing anti–IFN- autoantibodies should supplement testing for IFN- and IL-12 pathway defects in patients with recurrent infections with intracellular pathogens, especially with nontuberculous mycobacteria. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S Y Patel, R Doffinger, G Barcenas-Morales, and D S Kumararatne Genetically determined susceptibility to mycobacterial infection J. Clin. Pathol., September 1, 2008; 61(9): 1006 - 1012. [Abstract] [Full Text] [PDF] P. Sexton and A. C. Harrison Susceptibility to nontuberculous mycobacterial lung disease Eur. Respir. J., June 1, 2008; 31(6): 1322 - 1333. [Abstract] [Full Text] [PDF] A. Puel, C. Picard, M. Lorrot, C. Pons, M. Chrabieh, L. Lorenzo, M. Mamani-Matsuda, E. Jouanguy, D. Gendrel, and J.-L. Casanova Recurrent Staphylococcal Cellulitis and Subcutaneous Abscesses in a Child with Autoantibodies against IL-6 J. Immunol., January 1, 2008; 180(1): 647 - 654. [Abstract] [Full Text] [PDF] G. Plitas, U. I. Chaudhry, T. P. Kingham, J. R. Raab, and R. P. DeMatteo NK Dendritic Cells Are Innate Immune Responders to Listeria monocytogenes Infection J. Immunol., April 1, 2007; 178(7): 4411 - 4416. [Abstract] [Full Text] [PDF] P. Kelleher, A. Goodsall, A. Mulgirigama, H. Kunst, D. C. Henderson, R. Wilson, A. Newman-Taylor, and M. Levin Interferon-{gamma} therapy in two patients with progressive chronic pulmonary aspergillosis. Eur. Respir. J., June 1, 2006; 27(6): 1307 - 1310. [Abstract] [Full Text] [PDF] A. E. Medvedev, I. Sabroe, J. D. Hasday, and S. N. Vogel Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease Innate Immunity, June 1, 2006; 12(3): 133 - 150. [Abstract] [PDF] S. Y. Patel, L. Ding, M. R. Brown, L. Lantz, T. Gay, S. Cohen, L. A. Martyak, B. Kubak, and S. M. Holland Anti-IFN-{gamma} Autoantibodies in Disseminated Nontuberculous Mycobacterial Infections J. Immunol., October 1, 2005; 175(7): 4769 - 4776. [Abstract] [Full Text] [PDF]

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