SEARCH:   Advanced

Blood, 15 January 2004, Vol. 103, No. 2, pp. 717-724. Prepublished online as a Blood First Edition Paper on September 25, 2003; DOI 10.1182/blood-2003-01-0192. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-01-0192v1 103/2/717    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jordan, W. J. Articles by Ritter, M. A. Search for Related Content PubMed PubMed Citation Articles by Jordan, W. J. Articles by Ritter, M. A. Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation William J. Jordan, Paul A. Brookes, Richard M. Szydlo, John M. Goldman, Robert I. Lechler, and Mary A. Ritter From the Departments of Immunology and Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom. Despite the success of human leukocyte antigen (HLA) typing in allogeneic stem cell transplantation (SCT) it is rare to find an unrelated donor that is perfectly matched, making identification of "permissive" mismatches of paramount importance. Here, we describe novel associations between donor T-cell cytokine production during donor-antipatient mixed lymphocyte reactions (MLRs) and acute graft-versus-host disease (aGVHD). The data reveal positive correlations between both Th1-type and Th2-type cytokine production and GVHD and the assay established could potentially represent a useful tool for identification of permissible unrelated SCT donors. Associations between interleukin 13 (IL-13) levels and aGVHD were by far the strongest predictor of a GVHD (P = .0002). All patients suffering severe (grade III) aGVHD following SCT had donors who produced very high pretransplantation IL-13 responses, while those developing little or no aGVHD (grades 0-I) produced no IL-13 at all. IL-13 levels were independent of all other cytokines measured as well as cytotoxic T-lymphocyte precursor (CTLp) frequencies. The cytokines IL-5, interferon (IFN-), and tumor necrosis factor (TNF-) also predicted development of aGVHD (P < .05 for all 3), appearing to be coproduced in the assay and correlating with estimated CTLp frequencies. The data challenge the notion that aGVHD is purely a Th1-type cytokine-driven response, high-lighting a novel and highly significant link between the Th2-type cytokine IL-13 and aGVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. D. L. Savage, T. de Boer, K. V. Walburg, S. A. Joosten, K. van Meijgaarden, A. Geluk, and T. H. M. Ottenhoff Human Anti-Inflammatory Macrophages Induce Foxp3+GITR+CD25+ Regulatory T Cells, Which Suppress via Membrane-Bound TGF{beta}-1 J. Immunol., August 1, 2008; 181(3): 2220 - 2226. [Abstract] [Full Text] [PDF] J. H. Gerrits, J. van de Wetering, S. Postma, J. J. M. Drabbels, L. M. B. Vaessen, J. N. M. IJzermans, J. Rischen, F. H. J. Claas, W. Weimar, and N. M. van Besouw Stable T-cell reactivity after successful tapering of azathioprine in HLA-identical living-related kidney transplant recipients despite minor histocompatibility antigen mismatches Nephrol. Dial. Transplant., February 1, 2007; 22(2): 353 - 361. [Abstract] [Full Text] [PDF] M. Boniotto, W. J. Jordan, J. Eskdale, A. Tossi, N. Antcheva, S. Crovella, N. D. Connell, and G. Gallagher Human {beta}-Defensin 2 Induces a Vigorous Cytokine Response in Peripheral Blood Mononuclear Cells. Antimicrob. Agents Chemother., April 1, 2006; 50(4): 1433 - 1441. [Abstract] [Full Text] [PDF] J. E. Foley, U. Jung, A. Miera, T. Borenstein, J. Mariotti, M. Eckhaus, B. E. Bierer, and D. H. Fowler Ex Vivo Rapamycin Generates Donor Th2 Cells That Potently Inhibit Graft-versus-Host Disease and Graft-versus-Tumor Effects via an IL-4-Dependent Mechanism J. Immunol., November 1, 2005; 175(9): 5732 - 5743. [Abstract] [Full Text] [PDF] P. H. Tan, J. B. Yates, S.-A. Xue, C. Chan, W. J. Jordan, J. E. Harper, M. P. Watson, R. Dong, M. A. Ritter, R. I. Lechler, et al. Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression Blood, November 1, 2005; 106(9): 2936 - 2943. [Abstract] [Full Text] [PDF] K. Haraguchi, T. Takahashi, A. Matsumoto, T. Asai, Y. Kanda, M. Kurokawa, S. Ogawa, H. Oda, M. Taniguchi, H. Hirai, et al. Host-Residual Invariant NK T Cells Attenuate Graft-versus-Host Immunity J. Immunol., July 15, 2005; 175(2): 1320 - 1328. [Abstract] [Full Text] [PDF] P. H. Tan, S. C. Beutelspacher, S.-A. Xue, Y.-H. Wang, P. Mitchell, J. C. McAlister, D. F. P. Larkin, M. O. McClure, H. J. Stauss, M. A. Ritter, et al. Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy Blood, May 15, 2005; 105(10): 3824 - 3832. [Abstract] [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020