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Blood, 15 January 2004, Vol. 103, No. 2, pp. 725-731. Prepublished online as a Blood First Edition Paper on August 28, 2003; DOI 10.1182/blood-2002-11-3615. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-11-3615v1 103/2/725    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Casper, J. Articles by Freund, M. Search for Related Content PubMed PubMed Citation Articles by Casper, J. Articles by Freund, M. Related Collections Neoplasia Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Treosulfan and fludarabine: a new toxicity-reduced conditioning regimen for allogeneic hematopoietic stem cell transplantation Jochen Casper, Wolfgang Knauf, Thomas Kiefer, Daniel Wolff, Beate Steiner, Ulrich Hammer, Rudolf Wegener, Hans-Dieter Kleine, Stefan Wilhelm, Agnes Knopp, Gernot Hartung, Gottfried Dölken, and Mathias Freund From the Department of Hematology and Oncology and the Department of Forensic Medicine, University of Rostock, Rostock, Germany; the Department of Hematology and Oncology, Klinikum Benjamin Franklin, Free University of Berlin, Berlin, Germany; the Department of Hematology and Oncology, ErnstMoritz-Arndt University of Greifswald, Greifswald, Germany; and the East German Study Group for Hematology and Oncology (OSHO), Leipzig, Germany. New conditioning regimens are being explored to reduce toxicity and enable allogeneic bone marrow transplantation in patients not eligible for conventional transplantation. We have investigated treosulfan, an alkylating agent, with the aim of developing an efficient and reliable but less-toxic conditioning regimen. A series of 30 patients who were not eligible for standard conditioning therapy received transplants from HLA-matched related (n = 14) or unrelated (n = 16) donors after administration of treosulfan 10 g/m2 intravenously daily for 3 days and fludarabine 30 mg/m2 intravenously daily for 5 days. Patients receiving grafts from unrelated donors also were given rabbit antithymocyte globulin 10 mg/kg intravenously daily for 3 days. All patients achieved prompt neutrophil and platelet recovery. Extramedullary toxicity was generally mild with Common Toxicity Criteria (CTC) grade 3 or 4 attributable to the conditioning seen only with transaminases. Complete donor chimerism was achieved by 90% of the patients. Acute graft-versus-host disease (GVHD) grade III or IV developed in 14% of the patients and chronic GVHD in 39%. An estimated overall survival rate of 73% and an event-free survival rate of 49% have been reached after a median of 22 months (range, 7.4-33.4 months). In summary, the combination of treosulfan and fludarabine is a safe and efficient conditioning regimen. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Stelljes, M. Bornhauser, M. Kroger, J. Beyer, M. C. Sauerland, A. Heinecke, B. Berning, C. Scheffold, G. Silling, T. Buchner, et al. Conditioning with 8-Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia Blood, November 1, 2005; 106(9): 3314 - 3321. [Abstract] [Full Text] [PDF] C. Lotze, F. Schuler, W. H. Kruger, C. Hirt, M. Kirsch, S. Vogelgesang, C. A. Schmidt, and G. Dolken Combined immunoradiotherapy induces long-term remission of CNS relapse of peripheral, diffuse, large-cell lymphoma after allogeneic stem cell transplantation: Case study Neuro-oncol, October 1, 2005; 7(4): 508 - 510. [Abstract] [PDF]

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