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Blood, 1 February 2004, Vol. 103, No. 3, pp. 1026-1029. Prepublished online as a Blood First Edition Paper on October 2, 2003; DOI 10.1182/blood-2003-04-1339. This Article Full Text Full Text (PDF) Supplemental Tables All Versions of this Article: 2003-04-1339v1 103/3/1026    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Longman, R. S. Articles by Rice, C. M. Search for Related Content PubMed PubMed Citation Articles by Longman, R. S. Articles by Rice, C. M. Related Collections Immunobiology Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief report Presence of functional dendritic cells in patients chronically infected with hepatitis C virus Randy S. Longman, Andrew H. Talal, Ira M. Jacobson, Matthew L. Albert, and Charles M. Rice From The Rockefeller University, New York, NY; The New York Presbyterian Hospital, New York, NY; and the Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY. The absence of expanded numbers of hepatitis C virus (HCV)-reactive CD8+ T lymphocytes (CTLs) in patients chronically infected with HCV has led to the investigation of dendritic cell (DC) function in this population as a potential cause for this defect. Several studies have shown evidence for impaired monocyte-derived DCs in chronically infected patients. As it is difficult to reconcile these data with the fact that patients with chronic HCV are immune competent, we re-evaluated this finding, carefully assessing phenotypic markers and functional activity of patient DCs as compared with noninfected controls. In contrast to these prior studies, DCs from 13 of 13 chronic HCV patients expressed typical maturation markers. These mature DCs were capable of priming allogeneic T lymphocytes, as well as stimulating influenza-specific memory T cells. This finding is consistent with clinical and immunologic data that the deficit in the patient's immune repertoire is HCV-specific and suggests that refined models are required for understanding the role of DCs in HCV pathogenesis. (Blood. 2004;103:1026-1029) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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