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Blood, 1 February 2004, Vol. 103, No. 3, pp. 890-896. Prepublished online as a Blood First Edition Paper on August 14, 2003; DOI 10.1182/blood-2003-03-0900. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-03-0900v1 103/3/890    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Michel, M. Articles by Bussel, J. B. Search for Related Content PubMed PubMed Citation Articles by Michel, M. Articles by Bussel, J. B. Related Collections Hemostasis, Thrombosis, and Vascular Biology Clinical Trials and Observations Related Article in Blood Online Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura? Marc Michel, Nichola Cooper, Christelle Jean, Christine Frissora, and James B. Bussel From the Department of Pediatrics, Division of Hematology/Oncology, and Department of Medicine, Division of Gastroenterology, Weill Medical College of Cornell University, New York–Presbyterian Hospital, New York, NY. To determine the prevalence of Helicobacter pylori (H pylori) infection in North American patients with immune thrombocytopenic purpura (ITP) and the effect of H pylori eradication on the platelet count, a prospective study was performed. Seventy-four patients aged 10 years and older (mean age of 41 years) with chronic ITP and a platelet count below 60 x 109/L were enrolled. H pylori infection was found in 22% of patients by means of a breath test and could not be predicted by gastrointestinal symptoms. H pylori–positive patients (52.5 years of age) were older than H pylori–negative patients (38.5 years of age; P = .0035). Fifteen of the 16 H pylori–positive patients were treated and the bacteria was eradicated in 14 (93%). After 3 months, a significant response (platelet count > 50 x 109/L and doubling the initial count) was observed in only one patient. After a median follow-up of 11.5 months, none of the 14 patients had responded. Ten H pylori–negative patients treated with the same regimen also did not increase their platelet counts. In conclusion, unlike several previous reports, this study does not implicate H pylori in the pathogenesis of ITP since the prevalence of H pylori infection was low and eradication of H pylori did not positively influence the course of the ITP. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Helicobacter pylori and ITP: many questions, few answers Keith R. McCrae Blood 2004 103: 752-753. [Full Text] [PDF] Related Letter in Blood Online: Helicobacter pylori and chronic ITP: the discrepancy in the clinical responses to eradication therapy might be due to differences in the bacterial strains Toru Takahashi, Toshiaki Yujiri, and Yukio Tanizawa Blood 2004 104: 594. [Full Text] [PDF] This article has been cited by other articles: M. Ruggeri, S. Fortuna, and F. Rodeghiero Heterogeneity of terminology and clinical definitions in adult idiopathic thrombocytopenic purpura: a critical appraisal from a systematic review of the literature Haematologica, January 1, 2008; 93(1): 98 - 103. [Abstract] [Full Text] [PDF] G. Emilia, M. Luppi, P. Zucchini, M. Morselli, L. Potenza, F. Forghieri, F. Volzone, G. Jovic, G. Leonardi, A. Donelli, et al. Helicobacter pylori infection and chronic immune thrombocytopenic purpura: long-term results of bacterium eradication and association with bacterium virulence profiles Blood, December 1, 2007; 110(12): 3833 - 3841. [Abstract] [Full Text] [PDF] M. Franchini, M. Cruciani, C. Mengoli, G. Pizzolo, and D. Veneri Effect of Helicobacter pylori eradication on platelet count in idiopathic thrombocytopenic purpura: a systematic review and meta-analysis J. Antimicrob. Chemother., August 1, 2007; 60(2): 237 - 246. [Abstract] [Full Text] [PDF] V. M.E. Neefjes, H. Heijboer, and R. Y.J. Tamminga H. pylori infection in childhood chronic immune thrombocytopenic purpura Haematologica, April 1, 2007; 92(4): 576 - 576. [Abstract] [Full Text] [PDF] T. Takahashi, T. Yujiri, and Y. Tanizawa Helicobacter pylori and chronic ITP: the discrepancy in the clinical responses to eradication therapy might be due to differences in the bacterial strains Blood, July 15, 2004; 104(2): 594 - 594. [Full Text] [PDF]

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