|
|
Blood, 1 February 2004, Vol. 103, No. 3, pp. 890-896.
Prepublished online as a Blood First Edition Paper on August 14, 2003; DOI 10.1182/blood-2003-03-0900.
 Previous Article | Table of Contents | Next Article 
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Does Helicobater pylori initiate or perpetuate immune thrombocytopenic purpura?
Marc Michel,
Nichola Cooper,
Christelle Jean,
Christine Frissora, and
James B. Bussel
From the Department of Pediatrics, Division of Hematology/Oncology, and Department of Medicine, Division of Gastroenterology, Weill Medical College of Cornell University, New York–Presbyterian Hospital, New York, NY.
To determine the prevalence of Helicobacter pylori (H pylori) infection in North American patients with immune thrombocytopenic purpura (ITP) and the effect of H pylori eradication on the platelet count, a prospective study was performed. Seventy-four patients aged 10 years and older (mean age of 41 years) with chronic ITP and a platelet count below 60 x 109/L were enrolled. H pylori infection was found in 22% of patients by means of a breath test and could not be predicted by gastrointestinal symptoms. H pylori–positive patients (52.5 years of age) were older than H pylori–negative patients (38.5 years of age; P = .0035). Fifteen of the 16 H pylori–positive patients were treated and the bacteria was eradicated in 14 (93%). After 3 months, a significant response (platelet count > 50 x 109/L and doubling the initial count) was observed in only one patient. After a median follow-up of 11.5 months, none of the 14 patients had responded. Ten H pylori–negative patients treated with the same regimen also did not increase their platelet counts. In conclusion, unlike several previous reports, this study does not implicate H pylori in the pathogenesis of ITP since the prevalence of H pylori infection was low and eradication of H pylori did not positively influence the course of the ITP.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Article in Blood Online:
-
Helicobacter pylori and ITP: many questions, few answers
- Keith R. McCrae
Blood 2004 103: 752-753.
[Full Text]
[PDF]
Related Letter in Blood Online:
-
Helicobacter pylori and chronic ITP: the discrepancy in the clinical responses to eradication therapy might be due to differences in the bacterial strains
- Toru Takahashi, Toshiaki Yujiri, and Yukio Tanizawa
Blood 2004 104: 594.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
D. M. Arnold, A. Bernotas, I. Nazi, R. Stasi, M. Kuwana, Y. Liu, J. G. Kelton, and M. A. Crowther
Platelet count response to H. pylori treatment in patients with immune thrombocytopenic purpura with and without H. pylori infection: a systematic review
Haematologica,
June 1, 2009;
94(6):
850 - 856.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Stasi, A. Sarpatwari, J. B. Segal, J. Osborn, M. L. Evangelista, N. Cooper, D. Provan, A. Newland, S. Amadori, and J. B. Bussel
Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review
Blood,
February 5, 2009;
113(6):
1231 - 1240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ruggeri, S. Fortuna, and F. Rodeghiero
Heterogeneity of terminology and clinical definitions in adult idiopathic thrombocytopenic purpura: a critical appraisal from a systematic review of the literature
Haematologica,
January 1, 2008;
93(1):
98 - 103.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Arnold and R. Stasi
Does Helicobacter pylori Eradication Therapy Result in a Platelet Count Improvement in Adults with Immune Thrombocytopenic Purpura Regardless of H pylori Infection?
Hematology,
January 1, 2008;
2008(1):
31 - 32.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Stasi and D. Provan
Helicobacter pylori and Chronic ITP
Hematology,
January 1, 2008;
2008(1):
206 - 211.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Emilia, M. Luppi, P. Zucchini, M. Morselli, L. Potenza, F. Forghieri, F. Volzone, G. Jovic, G. Leonardi, A. Donelli, et al.
Helicobacter pylori infection and chronic immune thrombocytopenic purpura: long-term results of bacterium eradication and association with bacterium virulence profiles
Blood,
December 1, 2007;
110(12):
3833 - 3841.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Franchini, M. Cruciani, C. Mengoli, G. Pizzolo, and D. Veneri
Effect of Helicobacter pylori eradication on platelet count in idiopathic thrombocytopenic purpura: a systematic review and meta-analysis
J. Antimicrob. Chemother.,
August 1, 2007;
60(2):
237 - 246.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. M.E. Neefjes, H. Heijboer, and R. Y.J. Tamminga
H. pylori infection in childhood chronic immune thrombocytopenic purpura
Haematologica,
April 1, 2007;
92(4):
576 - 576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Takahashi, T. Yujiri, and Y. Tanizawa
Helicobacter pylori and chronic ITP: the discrepancy in the clinical responses to eradication therapy might be due to differences in the bacterial strains
Blood,
July 15, 2004;
104(2):
594 - 594.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Stasi and D. Provan
Management of Immune Thrombocytopenic Purpura in Adults
Mayo Clin. Proc.,
April 1, 2004;
79(4):
504 - 522.
[Abstract]
[PDF]
|
|
|
|
|
