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Blood, 15 February 2004, Vol. 103, No. 4, pp. 1373-1375.
Prepublished online as a Blood First Edition Paper on October 23, 2003; DOI 10.1182/blood-2003-08-2859.
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HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Brief report
Endothelial progenitor cells in infantile hemangioma
Ying Yu,
Alan F. Flint,
John B. Mulliken,
June K. Wu, and
Joyce Bischoff
From the Program in Vascular Biology, Division of Genetics, and Division of Plastic Surgery at Children's Hospital, Harvard Medical School, Boston, MA.
Infantile hemangioma is an endothelial tumor that grows rapidly after birth but slowly regresses during early childhood. Initial proliferation of hemangioma is characterized by clonal expansion of endothelial cells (ECs) and neovascularization. Here, we demonstrated mRNA encoding CD133-2, an important marker for endothelial progenitor cells (EPCs), predominantly in proliferating but not involuting or involuted hemangioma. Progenitor cells coexpressing CD133 and CD34 were detected by flow cytometry in 11 of 12 proliferating hemangioma specimens from children 3 to 24 months of age. Furthermore, in 4 proliferating hemangiomas, we showed that 0.14% to 1.6% of CD45– nucleated cells were EPCs that coexpressed CD133 and the EC marker KDR. This finding is consistent with the presence of KDR+ immature ECs in proliferating hemangioma. Our results suggest that EPCs contribute to the early growth of hemangioma. To our knowledge, this is the first study to show direct evidence of EPCs in a human vascular tumor.
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