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Blood, 15 March 2004, Vol. 103, No. 6, pp. 2214-2220. Prepublished online as a Blood First Edition Paper on November 26, 2003; DOI 10.1182/blood-2003-08-2978. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 2003-08-2978v1 103/6/2214    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Edelson, B. T. Articles by Zutter, M. M. Search for Related Content PubMed PubMed Citation Articles by Edelson, B. T. Articles by Zutter, M. M. Related Collections Immunobiology Cell Adhesion and Motility Signal Transduction Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Mast cell–mediated inflammatory responses require the 21 integrin Brian T. Edelson, Zhengzhi Li, Loretta K. Pappan, and Mary M. Zutter From the Departments of Pathology and Immunology and Cell Biology, Washington University School of Medicine, St Louis, MO; and the Departments of Pathology and Cancer Biology, Vanderbilt University School of Medicine, The Vanderbilt Clinic, Nashville, TN. Although the 21 integrin is widely expressed and has been extensively studied, it has not been previously implicated in mast cell biology. We observed that 2 integrin subunit-deficient mice exhibited markedly diminished neutrophil and interleukin-6 responses during Listeria monocytogenes– and zymosan-induced peritonitis. Since exudative neutrophils of wild-type mice expressed little 21 integrin, it seemed unlikely that this integrin mediated neutrophil migration directly. Here, we demonstrate constitutive 21 integrin expression on peritoneal mast cells. Although 2-null mice contain normal numbers of peritoneal mast cells, these 2-null cells do not support in vivo mast cell–dependent inflammatory responses. We conclude that 21 integrin provides a costimulatory function required for mast cell activation and cytokine production in response to infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Integrins, mast cells, and innate immunity Eric J. Brown Blood 2004 103: 1980-1981. [Full Text] [PDF] This article has been cited by other articles: T. Oki, K. Eto, K. Izawa, Y. Yamanishi, N. Inagaki, J. Frampton, T. Kitamura, and J. 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Integrin {alpha}IIb{beta}3 Induces the Adhesion and Activation of Mast Cells through Interaction with Fibrinogen J. Immunol., January 1, 2006; 176(1): 52 - 60. [Abstract] [Full Text] [PDF] H. Nechushtan and E. Razin Mast cells: must they always be different? Blood, January 1, 2006; 107(1): 1 - 2. [Full Text] [PDF] B. T. Edelson, T. P. Stricker, Z. Li, S. K. Dickeson, V. L. Shepherd, S. A. Santoro, and M. M. Zutter Novel collectin/C1q receptor mediates mast cell activation and innate immunity Blood, January 1, 2006; 107(1): 143 - 150. [Abstract] [Full Text] [PDF] P. R.-M. Siljander, S. Hamaia, A. R. Peachey, D. A. Slatter, P. A. Smethurst, W. H. Ouwehand, C. G. Knight, and R. W. Farndale Integrin Activation State Determines Selectivity for Novel Recognition Sites in Fibrillar Collagens J. Biol. Chem., November 12, 2004; 279(46): 47763 - 47772. [Abstract] [Full Text] [PDF] H. Matsushima, N. Yamada, H. Matsue, and S. 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