|
|
Blood, 15 April 2004, Vol. 103, No. 8, pp. 3102-3110.
Prepublished online as a Blood First Edition Paper on December 24, 2003; DOI 10.1182/blood-2003-09-3311.
 Previous Article | Table of Contents | Next Article 
IMMUNOBIOLOGY
Do thymically and strictly extrathymically developing T cells generate similar immune responses?
Marie-Ève Blais,
Gwladys Gérard,
Marianne M. Martinic,
Guillaume Roy-Proulx,
Rolf M. Zinkernagel, and
Claude Perreault
From the Guy-Bernier Research Center, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada; and Institute for Experimental Immunology, University Hospital, Zürich, Switzerland.
If present in sufficient numbers, could extrathymic T cells substitute for thymus-derived T cells? To address this issue, we studied extrathymic T cells that develop in athymic mice under the influence of oncostatin M (OM). In this model, extensive T-cell development is probably due to amplification of a minor pathway of T-cell differentiation taking place only in the lymph nodes. Extrathymic CD4 T cells expanded poorly and were deficient in providing B-cell help after infection with vesicular stomatitis virus (VSV) and lymphocytic choriomeningitis virus (LCMV). Compared with classic T cells, stimulated extrathymic CD8 T cells produced copious amounts of interferon  (IFN-), and their expansion was precocious but of limited amplitude because of a high apoptosis rate. Consequently, although extrathymic cytotoxic T lymphocytes (CTLs) responded to LCMV infection, as evidenced by the expansion of GP33-41 tetramer-positive CD8 T cells, they were unable to eradicate the virus. Our data indicate that the site of development impinges on T-cell quality and function and that extrathymic T cells functionally cannot substitute for classical thymic T cells. (Blood. 2004;103:3102-3110)
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M.-E. Blais, S. Brochu, M. Giroux, M.-P. Belanger, G. Dulude, R.-P. Sekaly, and C. Perreault
Why T Cells of Thymic Versus Extrathymic Origin Are Functionally Different
J. Immunol.,
February 15, 2008;
180(4):
2299 - 2312.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. H. Nguyen, S. Shashidhar, D. S. Chang, L. Ho, N. Kambham, M. Bachmann, J. M. Brown, and R. S. Negrin
The impact of regulatory T cells on T-cell immunity following hematopoietic cell transplantation
Blood,
January 15, 2008;
111(2):
945 - 953.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Ford, Z.-X. Zhang, W. Chen, and L. Zhang
Double-Negative T Regulatory Cells Can Develop Outside the Thymus and Do Not Mature from CD8+ T Cell Precursors.
J. Immunol.,
September 1, 2006;
177(5):
2803 - 2809.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Terra, I. Louis, R. Le Blanc, S. Ouellet, J. C. Zuniga-Pflucker, and C. Perreault
T-cell generation by lymph node resident progenitor cells
Blood,
July 1, 2005;
106(1):
193 - 200.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
