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Blood, 1 May 2004, Vol. 103, No. 9, pp. 3362-3364. Prepublished online as a Blood First Edition Paper on January 8, 2004; DOI 10.1182/blood-2003-09-3245. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-09-3245v1 103/9/3362    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kunisaki, Y. Articles by Fukui, Y. Search for Related Content PubMed PubMed Citation Articles by Kunisaki, Y. Articles by Fukui, Y. Related Collections Hematopoiesis and Stem Cells Immunobiology Phagocytes Red Cells Apoptosis Brief Reports Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Brief report Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor Yuya Kunisaki, Sadahiko Masuko, Mayuko Noda, Ayumi Inayoshi, Terukazu Sanui, Mine Harada, Takehiko Sasazuki, and Yoshinori Fukui From the Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan; the Department of Anatomy and Physiology, Saga Medical School, Saga, Japan; Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan; the International Medical Center of Japan, Tokyo, Japan; and PRESTO, Japan Science and Technology Agency, Saitama, Japan. Clearance of apoptotic cells by macrophages is considered important for prevention of inflammatory responses leading to tissue damage. The phosphatidylserine receptor (PSR), which specifically binds to phosphatidylserine (PS) exposed on the surface of apoptotic cells, mediates uptake of apoptotic cells in vitro, yet the physiologic relevance of PSR remains unknown. This issue was addressed by generating PSR-deficient (PSR-/-) mice. PSR-/- mice exhibited severe anemia and died during the perinatal period. In the PSR-/- fetal livers, erythroid differentiation was blocked at an early erythroblast stage. In addition, PSR-/- embryos exhibited thymus atrophy owing to a developmental defect of T-lymphoid cells. Clearance of apoptotic cells by macrophages was impaired in both liver and thymus of PSR-/- embryos. However, this did not induce up-regulation of inflammatory cytokines. These results indicate that during embryonic development, PSR-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoiesis, independently of the prevention of inflammatory responses. (Blood. 2004;103:3362-3364) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Clearance receptor controls death and differentiation Siamon Gordon Blood 2004 103: 3250. [Full Text] [PDF] This article has been cited by other articles: C. J. Webby, A. Wolf, N. Gromak, M. Dreger, H. Kramer, B. Kessler, M. L. Nielsen, C. Schmitz, D. S. Butler, J. R. Yates III, et al. Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing Science, July 3, 2009; 325(5936): 90 - 93. [Abstract] [Full Text] [PDF] B. N. Y. Setty and S. G. 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Henson Recognition ligands on apoptotic cells: a perspective J. Leukoc. Biol., May 1, 2006; 79(5): 896 - 903. [Abstract] [Full Text] [PDF] J. E. Mitchell, M. Cvetanovic, N. Tibrewal, V. Patel, O. R. Colamonici, M. O. Li, R. A. Flavell, J. S. Levine, R. B. Birge, and D. S. Ucker The Presumptive Phosphatidylserine Receptor Is Dispensable for Innate Anti-inflammatory Recognition and Clearance of Apoptotic Cells J. Biol. Chem., March 3, 2006; 281(9): 5718 - 5725. [Abstract] [Full Text] [PDF] P. R. Hoffmann, J. A. Kench, A. Vondracek, E. Kruk, D. L. Daleke, M. Jordan, P. Marrack, P. M. Henson, and V. A. Fadok Interaction between Phosphatidylserine and the Phosphatidylserine Receptor Inhibits Immune Responses In Vivo J. Immunol., February 1, 2005; 174(3): 1393 - 1404. [Abstract] [Full Text] [PDF] J. Manaka, T. Kuraishi, A. Shiratsuchi, Y. Nakai, H. Higashida, P. Henson, and Y. 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