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Blood, 1 July 2004, Vol. 104, No. 1, pp. 26-33.
Prepublished online as a Blood First Edition Paper on March 16, 2004; DOI 10.1182/blood-2004-01-0182.
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REVIEW ARTICLES
Antigen-induced regulatory T cells
Stephane Vigouroux,
Eric Yvon,
Ettore Biagi, and
Malcolm K. Brenner
From the Center for Cell and Gene Therapy and the Departments of Pediatrics and Medicine, Baylor College of Medicine, Texas Children's Hospital, and The Methodist Hospital, Houston, TX.
Regulatory T cells participate in immunologic homeostasis by active suppression of inappropriate immune responses. Regulatory T lymphocytes expressing CD4 and CD25 antigens and naturally present in the peripheral blood were the first to be phenotypically characterized. However, their small number and antigen nonspecific suppression has prompted efforts to identify and dissect antigen-specific regulatory T cells. In this review we discuss how antigen-specific regulatory T cells can be identified, the cellular and molecular mechanisms underlying their induction and activity, and the challenges facing their potential clinical application.
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