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Blood, 1 December 2004, Vol. 104, No. 12, pp. 3804-3812. Prepublished online as a Blood First Edition Paper on August 3, 2004; DOI 10.1182/blood-2004-05-1850. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-05-1850v1 104/12/3804    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Taylor, P. A. Articles by Blazar, B. R. Search for Related Content PubMed PubMed Citation Articles by Taylor, P. A. Articles by Blazar, B. R. Related Collections Immunobiology Transplantation Cell Adhesion and Motility Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection Patricia A. Taylor, Angela Panoskaltsis-Mortari, Jessica M. Swedin, Philip J. Lucas, Ronald E. Gress, Bruce L. Levine, Carl H. June, Jonathan S. Serody, and Bruce R. Blazar From the University of Minnesota Cancer Center and Department of Pediatrics, Division of BMT, Minneapolis; Experimental Immunology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD; The Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia; and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill. Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality after bone marrow transplantation (BMT). CD4+CD25+ immune regulatory T cells (Tregs), long recognized for their critical role in induction and maintenance of self-tolerance and prevention of autoimmunity, are also important in the regulation of immune responses in allogeneic bone marrow (BM) and solid organ transplantation. Published data indicate that ex vivo activated and expanded donor Tregs result in significant inhibition of lethal GVHD. This study provides a direct comparison of LSelhi and LSello Tregs for GVHD inhibition and for the promotion of allogeneic BM engraftment. Imaging of green fluorescent protein–positive effectors in GVHD control mice and LSelhi and LSello Treg-treated mice vividly illustrate the multisystemic nature of GVHD and the profound inhibition of GVHD by LSelhi Tregs. Data indicate that LSelhi Tregs interfere with the activation and expansion of GVHD effector T cells in secondary lymphoid organs early after BMT. Either donor- or host-type LSelhi, but not LSello, Tregs potently increased donor BM engraftment in sublethally irradiated mice, an event occurring independently of transforming growth factor signaling of host T cells. These data indicate that Treg cellular therapy warrants clinical consideration for the inhibition of GVHD and the promotion of alloengraftment. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Zheng, Y. Liu, G. Qin, P.-L. Chan, H. Mao, K.-T. Lam, D. B. Lewis, Y.-L. Lau, and W. Tu Efficient Induction and Expansion of Human Alloantigen-Specific CD8 Regulatory T Cells from Naive Precursors by CD40-Activated B Cells J. Immunol., September 15, 2009; 183(6): 3742 - 3750. [Abstract] [Full Text] [PDF] A. M. Wolf, K. Eller, R. Zeiser, C. Durr, U. V. 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