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Blood, 15 August 2004, Vol. 104, No. 4, pp. 1010-1016. Prepublished online as a Blood First Edition Paper on May 4, 2004; DOI 10.1182/blood-2004-03-0989. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-03-0989v1 104/4/1010    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Baumann, C. I. Articles by Fleming, W. H. Search for Related Content PubMed PubMed Citation Articles by Baumann, C. I. Articles by Fleming, W. H. Related Collections Hematopoiesis and Stem Cells Red Cells Cell Adhesion and Motility Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors Christina I. Baumann, Alexis S. Bailey, Weiming Li, Michael J. Ferkowicz, Mervin C. Yoder, and William H. Fleming From the Center for Hematologic Malignancies, Division of Hematology and Medical Oncology, Oregon Health & Sciences University, Portland, OR; and the Department of Pediatrics/Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN. Platelet endothelial cell adhesion molecule-1 (PECAM-1) (CD31) is an adhesion molecule expressed on endothelial cells and subsets of leukocytes. Analysis of phenotypically defined hematopoietic stem cells (HSCs) from the yolk sac, fetal liver, and adult bone marrow demonstrates CD31 expression on these cells throughout development. CD31+ c-kit+ cells, but not CD31– c-kit+ cells, isolated from day-9.5 yolk sac give rise to multilineage hematopoiesis in vivo. Further evaluation of the CD31+ lineage marker–negative fraction of adult bone marrow reveals functionally distinct cell subsets. Transplantation of CD31+ Lin– c-kit– cells fails to protect lethally irradiated recipients, while CD31+ Lin– c-kit+ Sca-1– cells (CD31+ Sca-1–) provide radioprotection in the absence of long-term donor-derived hematopoiesis. Although donor-derived leukocytes were not detected in CD31+ Sca-1– recipients, donor-derived erythroid cells were transiently produced during the initial phases of bone marrow recovery. These results demonstrate CD31 expression on hematopoietic stem cells throughout ontogeny and identify a population of CD31+ short-term erythroid progenitors cells that confer protection from lethal doses of radiation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. C. Goldman, A. S. Bailey, D. L. Pfaffle, A. Al Masri, J. L. Christian, and W. H. Fleming BMP4 regulates the hematopoietic stem cell niche Blood, November 12, 2009; 114(20): 4393 - 4401. [Abstract] [Full Text] [PDF] X.-M. Li, Z. Hu, M. L. Jorgenson, and W. B. Slayton High Levels of Acetylated Low-Density Lipoprotein Uptake and Low Tyrosine Kinase With Immunoglobulin and Epidermal Growth Factor Homology Domains-2 (Tie2) Promoter Activity Distinguish Sinusoids From Other Vessel Types in Murine Bone Marrow Circulation, November 10, 2009; 120(19): 1910 - 1918. [Abstract] [Full Text] [PDF] D. Mariappan, J. Winkler, S. Chen, H. Schulz, J. 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