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Blood, 15 August 2004, Vol. 104, No. 4, pp. 1110-1119. Prepublished online as a Blood First Edition Paper on May 6, 2004; DOI 10.1182/blood-2003-10-3635. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-10-3635v1 104/4/1110    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chu, Y.-W. Articles by Gress, R. E. Search for Related Content PubMed PubMed Citation Articles by Chu, Y.-W. Articles by Gress, R. E. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function Yu-Waye Chu, Sarfraz A. Memon, Susan O. Sharrow, Frances T. Hakim, Michael Eckhaus, Philip J. Lucas, and Ronald E. Gress From the Experimental Immunology Branch and the Experimental Transplantation and Immunology Branch, Center for Cancer Research, and the Veterinary Resources Program, Office of Research Services, National Institutes of Health (NIH), Bethesda, MD. Interleukin 7 (IL-7) is critical in maintaining thymic-dependent and thymic-independent pathways of T-cell homeostasis. T-cell receptor (TCR) rearrangement excision circles (TRECs) have been used as markers for recent thymic emigrants (RTEs) in assessing human thymic function. To study the thymic and peripheral effects of IL-7 on RTEs, we measured TREC content and peripheral naive T-cell subsets and turnover in IL-7-treated mice. Short-term administration of IL-7 into thymus-intact mice resulted in increased total TREC numbers, consistent with RTE accumulation. Decreases in TREC frequency were attributable to dilution secondary to increased cell turnover. Significantly, IL-7 administration into thymectomized mice resulted in patterns of decreased TREC frequency and increased total TREC number similar to those in IL-7-treated thymus-intact mice. Distinct patterns of naive cell and RTE distribution among peripheral immune organs and altered expression of CD11a were observed following IL-7 treatment in thymus-intact and thymectomized mice. These results demonstrate (1) that total TREC number and not TREC frequency accurately reflects quantitative changes in RTEs; (2) that short-term IL-7 administration results in preferential accumulations of RTEs among peripheral immune organs, accounting for the increase in TRECs in the total peripheral lymphoid pool; and (3) no evidence for regulation of thymic function by short-term IL-7 administration. (Blood. 2004;104:1110-1119) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: X. Chen, L. Fang, S. Song, T. B. Guo, A. Liu, and J. Z. Zhang Thymic Regulation of Autoimmune Disease by Accelerated Differentiation of Foxp3+ Regulatory T Cells through IL-7 Signaling Pathway J. Immunol., November 15, 2009; 183(10): 6135 - 6144. [Abstract] [Full Text] [PDF] K. M. Williams, P. J. Lucas, C. V. Bare, J. Wang, Y.-W. Chu, E. Tayler, V. Kapoor, and R. E. 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