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 Blood, 15 August 2004, Vol. 104, No. 4, pp. 933-941.
Prepublished online as a Blood First Edition Paper on May 4, 2004; DOI 10.1182/blood-2003-11-4013.

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CHEMOKINES

Expression of the chemokine receptor CCR2 on immature B cells negatively regulates their cytoskeletal rearrangement and migration

Liat Flaishon, Shirly Becker-Herman, Gili Hart, Yoram Levo, William A. Kuziel, and Idit Shachar

From the Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; the Sourasky Medical Center, Tel-Aviv, Israel; and Autoimmune and Inflammatory Diseases, Protein Design Labs, Inc, Fremont, CA.

Immature B cells are targeted to specific areas in the spleen, where a fraction of these cells receive signals that induce them to mature and participate in the immune response. In this study, we show that the C-C chemokine receptor 2 (CCR2) is transcribed in immature B cells, while its message is dramatically down-regulated at the mature stage. CCR2-deficient cells exhibit up-regulation of chemokine-induced actin polymerization, migration, and homing to the lymph nodes of immature B cells. In addition, we demonstrate that control of homing by CCR2 is mediated by its ligand, CCL2/JE, which is secreted by B cells and down-regulates the stromal derived factor-1 (SDF-1) signaling cascade. Thus, this study describes an additional, previously uncharacterized, role for CCR2 and its ligand as negative regulators of the homing of immature B cells.


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Related Article in Blood Online:

CCR2: holding B cells back
Dan Jones
Blood 2004 104: 911-912. [Full Text] [PDF]



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G. Hart, T. Avin-Wittenberg, and I. Shachar
IL-15 regulates immature B-cell homing in an Ly49D-, IL-12 , and IL-18 dependent manner
Blood, January 1, 2008; 111(1): 50 - 59.
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G. Hart, L. Flaishon, S. Becker-Herman, and I. Shachar
Tight Regulation of IFN-{gamma} Transcription and Secretion in Immature and Mature B cells by the Inhibitory MHC Class I Receptor, Ly49G2
J. Immunol., October 15, 2005; 175(8): 5034 - 5042.
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