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Blood, 1 January 2005, Vol. 105, No. 1, pp. 199-206. Prepublished online as a Blood First Edition Paper on September 2, 2004; DOI 10.1182/blood-2004-05-1831. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-05-1831v1 105/1/199    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Massa, M. Articles by Tavazzi, L. Search for Related Content PubMed PubMed Citation Articles by Massa, M. Articles by Tavazzi, L. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction Margherita Massa, Vittorio Rosti, Maurizio Ferrario, Rita Campanelli, Isabella Ramajoli, Roberta Rosso, Gaetano M. De Ferrari, Marco Ferlini, Lucio Goffredo, Alessandra Bertoletti, Catherine Klersy, Alessandro Pecci, Remigio Moratti, and Luigi Tavazzi From the Biotechnology Laboratory, Organ Transplantation Laboratory, Department of Cardiology, Internal Medicine and Medical Oncology, Biometry and Clinical Epidemiology, Clinica Medica III, and Department of Clinical Chemistry, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy. Endothelial progenitor cell (EPC) mobilization has been reported following tissue damage, whereas no data are available regarding the mobilization of hematopoietic progenitor cells (HPCs). We performed the phenotypic and functional analysis of circulating CD34+ progenitor cells in patients with acute myocardial infarction (AMI), assessed from admission up to 60 days, in patients with stable angina pectoris (SA), and in healthy controls (CTRLs). In patients with AMI at admission (T0), the number of circulating CD34+ cells was higher (P < .001) than in CTRLs and became comparable with CTRLs within 60 days. Both the number of CD34+ cells coexpressing CD33, CD38, or CD117 and the number of HPCs was higher (P < .02 for all) in patients with AMI at T0 than in CTRLs, as was the number of hematopoietic colonies (P < .03). Patients with AMI (T0) had a significantly increased number of CD34+ vascular endothelial growth factor receptor 2–positive (VEGFR-2+) cells (P < .002) with respect to CTRLs, including CD34+ CD133+VEGFR-2+ and CD34+ CD117+VEGFR-2+ EPCs. The number of endothelial colonies was higher in patients with AMI (T0) than in CTRLs (P < .05). No significant difference was documented between patients with SA and CTRLs. Spontaneous mobilization of both HPCs and EPCs occurs within a few hours from the onset of AMI and is detectable until 2 months. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Bogos, F. Renyi-Vamos, J. Dobos, J. Tovari, G. Ostoros, and B. Dome Clin. Cancer Res., November 1, 2009; 15(21): 6740 - 6741. [Full Text] [PDF] G. Piaggio, V. Rosti, M. Corselli, F. Bertolotti, G. Bergamaschi, S. Pozzi, D. Imperiale, B. Chiavarina, E. Bonetti, F. Novara, et al. 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