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Blood, 15 February 2005, Vol. 105, No. 4, pp. 1823-1827. Prepublished online as a Blood First Edition Paper on October 21, 2004; DOI 10.1182/blood-2004-07-2832. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-07-2832v1 105/4/1823    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mommaas, B. Articles by Goulmy, E. Search for Related Content PubMed PubMed Citation Articles by Mommaas, B. Articles by Goulmy, E. Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1 Bregje Mommaas, Janine A. Stegehuis-Kamp, Astrid G. van Halteren, Michel Kester, Jürgen Enczmann, Peter Wernet, Gesine Kögler, Tuna Mutis, Anneke Brand, and Els Goulmy From the Department of Immunohematology and Blood Transfusion; the Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands; the Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich Heine University, Dusseldorf, Germany; and the Sanquin Blood Bank, Leiden, The Netherlands. Umbilical cord blood transplantation is applied as treatment for mainly pediatric patients with hematologic malignancies. The clinical results show a relatively low incidence of graft-versus-host disease and leukemia relapse. Since maternal cells traffic into the fetus during pregnancy, we questioned whether cord blood has the potential to generate cytotoxic T cells specific for the hematopoietic minor histocompatibility (H) antigen HA-1 that would support the graft-versus-leukemia effect. Here, we demonstrate the feasibility of ex vivo generation of minor H antigen HA-1-specific T cells from cord blood cells. Moreover, we observed pre-existing HA-1-specific T cells in cord blood samples. Both the circulating and the ex vivo-generated HA-1-specific T cells show specific and hematopoietic restricted lysis of human leukocyte antigen-A2pos/HA-1pos (HLA-A2pos/HA-1pos) target cells, including leukemic cells. The cord blood-derived HA-1-specific cytotoxic T cells are from child origin. Thus, the so-called naive cord blood can comprise cytotoxic T cells directed at the maternal minor H antigen HA-1. The apparent immunization status of cord blood may well contribute to the in vivo graft-versus-leukemia activity after transplantation. Moreover, since the fetus cannot be primed against Y chromosome-encoded minor H antigens, cord blood is an attractive stem cell source for male patients. (Blood. 2005;105:1823-1827) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. J. Hanley, C. R. Y. Cruz, B. Savoldo, A. M. Leen, M. Stanojevic, M. Khalil, W. Decker, J. J. Molldrem, H. Liu, A. P. Gee, et al. Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes Blood, August 27, 2009; 114(9): 1958 - 1967. [Abstract] [Full Text] [PDF] A L Feitsma, A H M van der Helm-van Mil, T W J Huizinga, R R P de Vries, and R E M Toes Protection against rheumatoid arthritis by HLA: nature and nurture Ann Rheum Dis, December 1, 2008; 67(Suppl_3): iii61 - iii63. [Abstract] [Full Text] [PDF] Q. Tang, B. Grzywacz, H. Wang, N. Kataria, Q. Cao, J. E. Wagner, B. R. Blazar, J. S. Miller, and M. R. Verneris Umbilical Cord Blood T Cells Express Multiple Natural Cytotoxicity Receptors after IL-15 Stimulation, but Only NKp30 Is Functional J. Immunol., October 1, 2008; 181(7): 4507 - 4515. [Abstract] [Full Text] [PDF] A. L. Feitsma, J. Worthington, A. H. M. van der Helm-van Mil, D. Plant, W. Thomson, J. Ursum, D. van Schaardenburg, I. E. van der Horst-Bruinsma, J. J. van Rood, T. W. J. Huizinga, et al. Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development PNAS, December 11, 2007; 104(50): 19966 - 19970. [Abstract] [Full Text] [PDF] A. Mullally and J. Ritz Beyond HLA: the significance of genomic variation for allogeneic hematopoietic stem cell transplantation Blood, February 15, 2007; 109(4): 1355 - 1362. [Abstract] [Full Text] [PDF] K. Schilbach, G. Kerst, S. Walter, M. Eyrich, D. Wernet, R. Handgretinger, W. Xie, H.-G. Rammensee, I. Muller, H.-J. Buhring, et al. Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction Blood, July 1, 2005; 106(1): 144 - 149. [Abstract] [Full Text] [PDF] W. Tse and M. J. Laughlin Umbilical Cord Blood Transplantation: A New Alternative Option Hematology, January 1, 2005; 2005(1): 377 - 383. [Abstract] [Full Text] [PDF]

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