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Blood, 1 March 2005, Vol. 105, No. 5, pp. 2132-2134. Prepublished online as a Blood First Edition Paper on November 23, 2004; DOI 10.1182/blood-2004-01-0366. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: 2004-01-0366v1 105/5/2132    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Choi, C. Articles by Beckhove, P. Search for Related Content PubMed PubMed Citation Articles by Choi, C. Articles by Beckhove, P. Related Collections Immunobiology Neoplasia Immunotherapy Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief report Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma Carmen Choi, Mathias Witzens, Marianna Bucur, Markus Feuerer, Nora Sommerfeldt, Andreas Trojan, Anthony Ho, Volker Schirrmacher, Hartmut Goldschmidt, and Philipp Beckhove From the Tumor Immunology Program, The German Cancer Research Center, Heidelberg, Germany; the Department of Hematology and Oncology, The University Hospital Heidelberg, Heidelberg, Germany; the Department of Experimental Rheumatology, Medical Clinic, Charité, Humboldt University, Berlin, Germany; and the Department of Oncology, University Hospital Zurich, Zurich, Switzerland. Multiple myeloma (MM) is one of the most common hematologic malignancies. Despite extensive therapeutical approaches, cures remain rare exceptions. An important issue for future immunologic treatments is the characterization of appropriate tumor-associated antigens. Recently, a highly glycosylated mucin MUC1 was detected on a majority of multiple myeloma cell lines. We analyzed bone marrow and peripheral blood of 68 patients with HLA-A2–positive myeloma for the presence and functional activity of CD8 T cells specific for the MUC1-derived peptide LLLLTVLTV. Forty-four percent of the patients with MM contained elevated frequencies of MUC1-specific CD8 T cells in freshly isolated samples from peripheral blood (PB) or bone marrow (BM) compared with corresponding samples from healthy donors. BM-residing T cells possessed a higher functional capacity upon specific reactivation than PB-derived T cells with regard to interferon (IFN-) secretion, perforin production, and cytotoxicity. 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