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Blood, 1 April 2005, Vol. 105, No. 7, pp. 2887-2890. Prepublished online as a Blood First Edition Paper on December 14, 2004; DOI 10.1182/blood-2004-06-2423. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-06-2423v1 105/7/2887    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Holm, A. M. Articles by Frøland, S. S. Search for Related Content PubMed PubMed Citation Articles by Holm, A. M. Articles by Frøland, S. S. Related Collections Brief Reports Chemokines, Cytokines, and Interleukins Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief report Abnormal interleukin-7 function in common variable immunodeficiency Are Martin Holm, Pål Aukrust, Jan Kristian Damås, Fredrik Müller, Bente Halvorsen, and Stig S. Frøland From the Section of Clinical Immunology and Infectious Diseases, Medical Department; the Research Institute for Internal Medicine; and the Department of Microbiology, Rikshospitalet/The National Hospital, Oslo, Norway. Common variable immunodeficiency (CVID) is characterized by low levels of circulating immunoglobulins, leading to frequent infections, particularly of the respiratory tract. Frequently, T-cell abnormalities are observed. Interleukin-7 (IL-7) is involved in the homeostasis of lymphocytes, and may be elevated in lymphopenia. Mutations of genes related to IL-7 may lead to severe immunodeficiency disorders. We report elevated plasma levels of circulating IL-7 in a subgroup of CVID. These patients have increased numbers of circulating CD8+ T cells with decreased apoptosis and a predominance of CC chemokine receptor 7- (CCR7-) effector-memory T cells. Moreover, in some of these patients there is impaired response to IL-7 as assessed by in vitro proliferation and secretion of interferon and transforming growth factor . These findings suggest novel pathogenic mechanisms and specific targets for further research in CVID. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. Rezaei, A. Aghamohammadi, S. D. Siadat, M. Moin, Z. Pourpak, M. Nejati, H. Ahmadi, S. Kamali, D. Norouzian, B. Tabaraei, et al. Serum Bactericidal Antibody Responses to Meningococcal Polysaccharide Vaccination as a Basis for Clinical Classification of Common Variable Immunodeficiency Clin. Vaccine Immunol., April 1, 2008; 15(4): 607 - 611. [Abstract] [Full Text] [PDF] A. Malaspina, S. Moir, D. G. Chaitt, C. A. Rehm, S. Kottilil, J. Falloon, and A. S. Fauci Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7 Blood, March 1, 2007; 109(5): 2086 - 2088. [Abstract] [Full Text] [PDF] J. Ho, S. Moir, A. Malaspina, M. L. Howell, W. Wang, A. C. DiPoto, M. A. O'Shea, G. A. Roby, R. Kwan, J. M. Mican, et al. Two overrepresented B cell populations in HIV-infected individuals undergo apoptosis by different mechanisms PNAS, December 19, 2006; 103(51): 19436 - 19441. [Abstract] [Full Text] [PDF] S. E. Johnson, N. Shah, A. Panoskaltsis-Mortari, and T. W. LeBien Murine and Human IL-7 Activate STAT5 and Induce Proliferation of Normal Human Pro-B Cells J. Immunol., December 1, 2005; 175(11): 7325 - 7331. [Abstract] [Full Text] [PDF]

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