Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 15 April 2005, Vol. 105, No. 8, pp. 3312-3318.
Prepublished online as a Blood First Edition Paper on December 30, 2004; DOI 10.1182/blood-2004-10-3915.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2004-10-3915v1
105/8/3312    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ma, Z.
Right arrow Articles by Kawano, M. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ma, Z.
Right arrow Articles by Kawano, M. M.
Related Collections
Right arrow Immunobiology
Right arrow Neoplasia
Right arrow Apoptosis
Right arrow Cell Cycle
Right arrow Signal Transduction
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

NEOPLASIA

Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells

Zi Ma, Ken-ichiro Otsuyama, Shangqin Liu, Saeid Abroun, Hideaki Ishikawa, Naohiro Tsuyama, Masanori Obata, Fu-Jun Li, Xu Zheng, Yasuko Maki, Koji Miyamoto, and Michio M. Kawano

From the Department of Bio-Signal Analysis, Applied Medical Engineering Science (AMES), Graduate School of Medicine, Yamaguchi University, Yamaguchi, Japan; and Department of Kampo Medicine, Molecular Science, and Applied Medicine, Yamaguchi University School of Medicine, Yamaguchi University, Yamaguchi, Japan.

In the search for a more effective adjuvant therapy to treat multiple myeloma (MM), we investigated the effects of the traditional Chinese herbal medicines Huang-Lian-Jie-Du-Tang (HLJDT), Gui-Zhi-Fu-Ling-Wan (GZFLW), and Huang-Lian-Tang (HLT) on the proliferation and apoptosis of myeloma cells. HLJDT inhibited the proliferation of myeloma cell lines and the survival of primary myeloma cells, especially MPC-1- immature myeloma cells, and induced apoptosis in myeloma cell lines via a mitochondria-mediated pathway by reducing mitochondrial membrane potential and activating caspase-9 and caspase-3. Further experiments confirmed that Scutellaria radix was responsible for the suppressive effect of HLJDT on myeloma cell proliferation, and the baicalein in Scutellaria radix showed strong growth inhibition and induction of apoptosis in comparison with baicalin or wogonin. Baicalein as well as baicalin suppressed the survival in vitro of MPC-1- immature myeloma cells rather than MPC-1+ myeloma cells from myeloma patients. Baicalein inhibited the phosphorylation of IkB-{alpha}, which was followed by decreased expression of the IL-6 and XIAP genes and activation of caspase-9 and caspase-3. Therefore, HLJDT and Scutellaria radix have an antiproliferative effect on myeloma cells, especially MPC-1- immature myeloma cells, and baicalein may be responsible for the suppressive effect of Scutellaria radix by blocking IkB-{alpha} degradation. (Blood. 2005;105:3312-3318)


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Molecular Cancer TherapeuticsHome page
J.-I Chao, W.-C. Su, and H.-F. Liu
Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT
Mol. Cancer Ther., November 1, 2007; 6(11): 3039 - 3048.
[Abstract] [Full Text] [PDF]

Home page
 ASH ANNUAL MEETING ABSTRACTSHome page
Z. Ma, S. Liu, K.-i. Otsuyama, and M. M. Kawano
Baicalein Inhibits IL-6-Mediated Multiple Signaling Cascades through Jak Family Kinase in Human Myeloma Cells.
Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 3390 - 3390.
[Abstract]

Home page
 ASH ANNUAL MEETING ABSTRACTSHome page
K.-i. Otsuyama, Z. Ma, S. Liu, S. Abroun, H. Asaoku, and M. M. Kawano
PPAR{beta}-Mediated Suppression of the Growth and Survival in Human Myeloma Cells Conteracting NF-kB Activity.
Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 5053 - 5053.
[Abstract]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020