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Blood, 1 May 2005, Vol. 105, No. 9, pp. 3488-3492.
Prepublished online as a Blood First Edition Paper on January 13, 2005; DOI 10.1182/blood-2004-07-2839.
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HEMATOPOIESIS
Identification of a human B-cell/myeloid common progenitor by the absence of CXCR4
Yong-Hao Hou,
Edward F. Srour,
Heather Ramsey,
Richard Dahl,
Hal E. Broxmeyer, and
Robert Hromas
From the Departments of Biochemistry, Internal Medicine, and Microbiology/Immunology, Walther Oncology Institute, Indiana University Cancer Center, Indianapolis, IN; and Cancer Research and Treatment Center, University of New Mexico Health Science Center, Albuquerque, NM.
CXCR4 is a chemokine receptor required for hematopoietic stem cell engraftment and B-cell development. This study found that a small fraction of primitive CD34+/CD19+ B-cell progenitors do not express CXCR4. These CD34+/CD19+/CXCR4- cells were also remarkable for the relative lack of primitive myeloid or lymphoid surface markers. When placed in B-lymphocyte culture conditions these cells matured to express CXCR4 and other surface antigens characteristic of B cells. Surprisingly, when placed in a myeloid culture environment, the CXCR4- B-cell progenitors could differentiate into granulocyte, macrophage, and erythroid cells at a high frequency. These data define a novel B-cell/myeloid common progenitor (termed the BMP) and imply a less restrictive pathway of myeloid versus lymphoid development than previously postulated.
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