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Blood, 1 May 2005, Vol. 105, No. 9, pp. 3535-3537. Prepublished online as a Blood First Edition Paper on December 2, 2004; DOI 10.1182/blood-2004-07-2676. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-07-2676v1 105/9/3535    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by BitMansour, A. Articles by Brown, J. M. Y. Search for Related Content PubMed PubMed Citation Articles by BitMansour, A. Articles by Brown, J. M. Y. Related Collections Hematopoiesis and Stem Cells Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Brief report Single infusion of myeloid progenitors reduces death from Aspergillus fumigatus following chemotherapy-induced neutropenia Andrew BitMansour, Thai M. Cao, Stephanie Chao, Sumana Shashidhar, and Janice M. Y. Brown From the Divisions of Bone Marrow Transplantation and Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, CA. Hematopoietic progenitors committed to the myeloid lineage, the common myeloid and granulocyte-monocyte progenitors (CMP/GMP), have been shown to protect against opportunistic pathogens following myeloablative radiation; however, the efficacy of this approach has not been studied in the setting of chemotherapy-induced neutropenia. In this mouse model, the infusion of CMP/GMP on the day after 5-fluorouracil (5-FU) administration (D+1) resulted in a significant increase in the number of splenic neutrophils by D+8 when compared with 5-FU–only controls (P = .02), the majority of which were CMP/GMP-derived (54%). Moreover, 19% and 28% of neutrophils in the blood and bone marrow, respectively, were CMP/GMP-derived. Survival following intranasal challenge with the fungus Aspergillus fumigatus was significantly higher in CMP/GMP-infused mice than the controls (56% and 33% respectively; P = .019). Thus, a single infusion of CMP/GMP enhances tissue neutrophil content and increases survival against a lethal challenge with A fumigatus in the setting of chemotherapy-induced neutropenia. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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