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 Blood, 1 July 2005, Vol. 106, No. 1, pp. 167-174.
Prepublished online as a Blood First Edition Paper on March 10, 2005; DOI 10.1182/blood-2004-12-4931.

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IMMUNOBIOLOGY

The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation

Achim A. Jungbluth, Scott Ely, Maurizio DiLiberto, Ruben Niesvizky, Barbara Williamson, Denise Frosina, Yao-Tseng Chen, Nina Bhardwaj, Selina Chen-Kiang, Lloyd J. Old, and Hearn Jay Cho

From the New York Branch, Ludwig Institute for Cancer Research, New York, NY; Department of Pathology, Weill Medical College of Cornell University, New York, NY; Division of Hematology/Medical Oncology, Department of Medicine, Weill Medical College of Cornell University, New York, NY; Graduate Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences, New York, NY; and the New York University School of Medicine, New York, NY.

Multiple myeloma is a malignancy of plasma cells. Vaccine immunotherapy is among the novel therapeutic strategies under investigation for this disease. To identify myeloma-associated antigens as potential targets for vaccine immunotherapy, we surveyed a comprehensive panel of bone marrow specimens from patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma for expression of cancer-testis (CT) antigens. Immunohistochemistry (IHC) demonstrated that 82% of stage-III myeloma specimens expressed the CT antigen CT7 (also known as melanoma antigen C1 [MAGE-C1]) and 70% expressed MAGE-A3/6. Messenger RNA for CT7 and MAGE-A family members was detected in 87% and 100% of stage-III samples, respectively. CT7 protein expression increased with advanced stage of disease. Higher levels of CT7 and MAGE-A3/6 proteins also correlated with elevated plasma-cell proliferation. These results show that CT7 and MAGE-A3/6 are promising myeloma-associated antigens for application in vaccine immunotherapy. Furthermore, the common expression and correlation with proliferation suggest a possible pathogenic role for these proteins in myeloma.


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Related Article in Blood Online:

Should MAGE be the rage in myeloma?
Carol Ann Huff and Judith E. Karp
Blood 2005 106: 5. [Full Text] [PDF]





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