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 Blood, 1 July 2005, Vol. 106, No. 1, pp. 201-206.
Prepublished online as a Blood First Edition Paper on March 17, 2005; DOI 10.1182/blood-2004-11-4240.

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IMMUNOBIOLOGY

CD8{alpha}–11b+ dendritic cells but not CD8{alpha}+ dendritic cells mediate cross-tolerance toward intestinal antigens

Yeonseok Chung, Jae-Hoon Chang, Mi-Na Kweon, Paul D. Rennert, and Chang-Yuil Kang

From the Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Kwanak-Gu, Seoul, Korea; the Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea; and the Department of Immunology, Biogen Idec, Cambridge, MA.

Cross-presentation is a critical process by which antigen is displayed to CD8 T cells to induce tolerance. It is believed that CD8{alpha}+ dendritic cells (DCs) are responsible for cross-presentation, suggesting that the CD8{alpha}+ DC population is capable of inducing both cross-priming and cross-tolerance to antigen. We found that cross-tolerance against intestinal soluble antigen was abrogated in C57BL/6 mice lacking mesenteric lymph nodes (MLNs) and Peyer patches (PPs), whereas mice lacking PPs alone were capable of developing CD8 T-cell tolerance. CD8{alpha}–CD11b+ DCs but not CD8{alpha}+ DCs in the MLNs present intestinal antigens to relevant CD8 T cells, while CD8{alpha}+ DCs but not CD8{alpha}–CD11b+ DCs in the spleen exclusively cross-present intravenous soluble antigen. Thus, CD8{alpha}–CD11b+ DCs in the MLNs play a critical role for induction of cross-tolerance to dietary proteins.


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