SEARCH:   Advanced

Blood, 15 December 2005, Vol. 106, No. 13, pp. 4054-4056. Prepublished online as a Blood First Edition Paper on August 25, 2005; DOI 10.1182/blood-2005-05-1866. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-05-1866v1 106/13/4054    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gleissner, B. Articles by Thiel, E. Search for Related Content PubMed PubMed Citation Articles by Gleissner, B. Articles by Thiel, E. Related Collections Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Brief report CD10- pre-B acute lymphoblastic leukemia (ALL) is a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations: results of the German Multicenter Trials for Adult ALL (GMALL) Beate Gleissner, Nicola Goekbuget, Harald Rieder, Renate Arnold, Stefan Schwartz, Helmut Diedrich, Claudia Schoch, Barbara Heinze, Christa Fonatsch, Claus R. Bartram, Dieter Hoelzer, Eckhard Thiel, for the GMALL Study Group From the Department of Internal Medicine III, Campus Benjamin Franklin, Charité Universitätsmedizin, Berlin, Germany; Department of Hematology, Goethe University, Frankfurt, Germany; Institute of Human Genetics and Anthropology, Heinrich-Heine Universität, Düsseldorf, Germany; Department of Hematology and Oncology, Campus Virchow, Charité Universitätsmedizin, Berlin, Germany; Department of Hematology and Oncology, Medical University of Hannover, Germany; Laboratory for Leukemia-Diagnostics, Department of Internal Medicine III, University Hospital Großhadern, Munich, Germany; Laboratory for Tumor Cytogenetics, University of Ulm, Germany; Department of Human Genetics, KIMCL, Medical Institute for Medical Biology, University of Vienna, Austria; and Institute of Human Genetics, University of Heidelberg, Germany. Immunophenotyping disclosed CD10 negativity in 70 of 2408 cases of B-lineage acute lymphoblastic leukemia (ALL), although other criteria followed classification of pre-B ALL (eg, cytoplasmic immunoglobulin positivity). These blasts showed high myeloid antigen expression (60% CD65 positivity) and reacted with antibody 7.1 in 95% of the cases. MLL-AF4 fusion transcripts or an 11q23/MLL rearrangement or both were evident in 46 of 56 samples (82%). Although 83% of the patients achieved complete remission, the remission duration remained remarkably low: 141 days for MLL rearrangement-positive and 245 days for MLL rearrangement-negative CD10- pre-B ALL. Thus, the overall survival probability 3 years after diagnosis was 0.34 ± 0.20 SE in MLL-rearrangement-negative versus 0.12 ± 0.06 SE in MLL rearrangement-positive CD10- pre-B ALL. Our data identify CD10- cytoplasmic immunoglobulin-positive pre-B ALL as a rare (2.2%) but distinct immuno-subtype of adult ALL that is characterized by a high MLL rearrangement rate and a worse outcome. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Burmeister, C. Meyer, S. Schwartz, J. Hofmann, M. Molkentin, E. Kowarz, B. Schneider, T. Raff, R. Reinhardt, N. Gokbuget, et al. The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group Blood, April 23, 2009; 113(17): 4011 - 4015. [Abstract] [Full Text] [PDF] A. Attarbaschi, G. Mann, M. Konig, M. Steiner, S. Strehl, A. Schreiberhuber, B. Schneider, C. Meyer, R. Marschalek, A. Borkhardt, et al. Mixed Lineage Leukemia-Rearranged Childhood Pro-B and CD10-Negative Pre-B Acute Lymphoblastic Leukemia Constitute a Distinct Clinical Entity. Clin. Cancer Res., May 15, 2006; 12(10): 2988 - 2994. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020