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Blood, 15 July 2005, Vol. 106, No. 2, pp. 408-418. Prepublished online as a Blood First Edition Paper on March 29, 2005; DOI 10.1182/blood-2004-07-2761. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-07-2761v1 106/2/408    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Reed, J. C. Articles by Pellecchia, M. Search for Related Content PubMed PubMed Citation Articles by Reed, J. C. Articles by Pellecchia, M. Related Collections Neoplasia Apoptosis Free Research Articles Review Articles Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  REVIEW IN TRANSLATIONAL HEMATOLOGY Apoptosis-based therapies for hematologic malignancies John C. Reed, and Maurizio Pellecchia From the Burnham Institute, La Jolla, CA. Abstract Apoptosis is an intrinsic cell death program that plays critical roles in tissue homeostasis, especially in organs where high rates of daily cell production are offset by rapid cell turnover. The hematopoietic system provides numerous examples attesting to the importance of cell death mechanisms for achieving homeostatic control. Much has been learned about the mechanisms of apoptosis of lymphoid and hematopoietic cells since the seminal observation in 1980 that glucocorticoids induce DNA fragmentation and apoptosis of thymocytes and the demonstration in 1990 that depriving colony-stimulating factors from factor-dependent hematopoietic cells causes programmed cell death. From an understanding of the core components of the apoptosis machinery at the molecular and structural levels, many potential new therapies for leukemia and lymphoma are emerging. In this review, we introduce some of the drug discovery targets thus far identified within the core apoptotic machinery and describe some of the progress to date toward translating our growing knowledge about these targets into new therapies for cancer and leukemia. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Chen, Y. Dai, X.-Y. Pei, and S. 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