SEARCH:   Advanced

Blood, 15 July 2005, Vol. 106, No. 2, pp. 419-427. Prepublished online as a Blood First Edition Paper on March 22, 2005; DOI 10.1182/blood-2004-09-3507. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-09-3507v1 106/2/419    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sordi, V. Articles by Piemonti, L. Search for Related Content PubMed PubMed Citation Articles by Sordi, V. Articles by Piemonti, L. Related Collections Hematopoiesis and Stem Cells Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets Valeria Sordi, Maria Luisa Malosio, Federica Marchesi, Alessia Mercalli, Raffaella Melzi, Tiziana Giordano, Nathalie Belmonte, Giuliana Ferrari, Biagio Eugenio Leone, Federico Bertuzzi, Gianpaolo Zerbini, Paola Allavena, Ezio Bonifacio, and Lorenzo Piemonti From the Telethon-Juvenile Diabetes Research Foundation Center for Cell Replacement, the H. S. Raffaele-Telethon Institute for Gene Therapy (HSR-TIGET), and the Renal Pathophysiology Laboratory, Division of Medicine, San Raffaele Scientific Institute, Via Olgettina, Milan Italy; the Department of Immunology and Cell Biology, "Mario Negri" Institute, Milan, Italy; and the Department of Surgery, University of Milano-Bicocca, Milan, Italy. Bone marrow–derived mesenchymal stem cells (BM-MSCs) are stromal cells with the ability to proliferate and differentiate into many tissues. Although they represent powerful tools for several therapeutic settings, mechanisms regulating their migration to peripheral tissues are still unknown. Here, we report chemokine receptor expression on human BM-MSCs and their role in mediating migration to tissues. A minority of BM-MSCs (2% to 25%) expressed a restricted set of chemokine receptors (CXC receptor 4 [CXCR4], CX3C receptor 1 [CX3CR1], CXCR6, CC chemokine receptor 1 [CCR1], CCR7) and, accordingly, showed appreciable chemotactic migration in response to the chemokines CXC ligand 12 (CXCL12), CX3CL1, CXCL16, CC chemokine ligand 3 (CCL3), and CCL19. Using human pancreatic islets as an in vitro model of peripheral tissue, we showed that islet supernatants released factors able to attract BM-MSCs in vitro, and this attraction was principally mediated by CX3CL1 and CXCL12. Moreover, cells with features of BM-MSCs were detected within the pancreatic islets of mice injected with green fluorescent protein (GFP)–positive BM. A population of bona fide MSCs that also expressed CXCR4, CXCR6, CCR1, and CCR7 could be isolated from normal adult human pancreas. This study defines the chemokine receptor repertoire of human BM-MSCs that determines their migratory activity. Modulation of homing capacity may be instrumental for harnessing the therapeutic potential of BM-MSCs. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Tommila, A. Jokilammi, P. Terho, T. Wilson, R. Penttinen, and E. Ekholm Hydroxyapatite coating of cellulose sponges attracts bone-marrow-derived stem cells in rat subcutaneous tissue J R Soc Interface, October 6, 2009; 6(39): 873 - 880. [Abstract] [Full Text] [PDF] M. Kumamoto, T. Nishiwaki, N. Matsuo, H. Kimura, and K. Matsushima Minimally cultured bone marrow mesenchymal stem cells ameliorate fibrotic lung injury Eur. Respir. J., September 1, 2009; 34(3): 740 - 748. [Abstract] [Full Text] [PDF] G. M. Spaggiari, H. Abdelrazik, F. Becchetti, and L. Moretta MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2 Blood, June 25, 2009; 113(26): 6576 - 6583. [Abstract] [Full Text] [PDF] I. U. Schraufstatter, R. G. DiScipio, M. Zhao, and S. K. Khaldoyanidi C3a and C5a Are Chemotactic Factors for Human Mesenchymal Stem Cells, Which Cause Prolonged ERK1/2 Phosphorylation J. Immunol., March 15, 2009; 182(6): 3827 - 3836. [Abstract] [Full Text] [PDF] P. J. Mishra, P. J. Mishra, J. W. Glod, and D. Banerjee Mesenchymal Stem Cells: Flip Side of the Coin Cancer Res., February 15, 2009; 69(4): 1255 - 1258. [Abstract] [Full Text] [PDF] C. Kyriakou, N. Rabin, A. Pizzey, A. Nathwani, and K. Yong Factors that influence short-term homing of human bone marrow-derived mesenchymal stem cells in a xenogeneic animal model Haematologica, October 1, 2008; 93(10): 1457 - 1465. [Abstract] [Full Text] [PDF] T. Morito, T. Muneta, K. Hara, Y.-J. Ju, T. Mochizuki, H. Makino, A. Umezawa, and I. Sekiya Synovial fluid-derived mesenchymal stem cells increase after intra-articular ligament injury in humans Rheumatology, August 1, 2008; 47(8): 1137 - 1143. [Abstract] [Full Text] [PDF] I. A. Potapova, P. R. Brink, I. S. Cohen, and S. V. Doronin Culturing of Human Mesenchymal Stem Cells as Three-dimensional Aggregates Induces Functional Expression of CXCR4 That Regulates Adhesion to Endothelial Cells J. Biol. Chem., May 9, 2008; 283(19): 13100 - 13107. [Abstract] [Full Text] [PDF] M. Sasaki, R. Abe, Y. Fujita, S. Ando, D. Inokuma, and H. Shimizu Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type J. Immunol., February 15, 2008; 180(4): 2581 - 2587. [Abstract] [Full Text] [PDF] L V. di Bonzo, I Ferrero, C Cravanzola, K Mareschi, D Rustichell, E Novo, F Sanavio, S Cannito, E Zamara, M Bertero, et al. Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: engraftment and hepatocyte differentiation versus profibrogenic potential Gut, February 1, 2008; 57(2): 223 - 231. [Abstract] [Full Text] [PDF] E. Jones and D. McGonagle Human bone marrow mesenchymal stem cells in vivo Rheumatology, February 1, 2008; 47(2): 126 - 131. [Abstract] [Full Text] [PDF] S. Chandran, D. Hunt, A. Joannides, C. Zhao, A. Compston, and R. J.M Franklin Myelin repair: the role of stem and precursor cells in multiple sclerosis Phil Trans R Soc B, January 12, 2008; 363(1489): 171 - 183. [Abstract] [Full Text] [PDF] M. Shi, J. Li, L. Liao, B. Chen, B. Li, L. Chen, H. Jia, and R. C. Zhao Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice Haematologica, July 1, 2007; 92(7): 897 - 904. [Abstract] [Full Text] [PDF] Y N Kallis, M R Alison, and S J Forbes Bone marrow stem cells and liver disease Gut, May 1, 2007; 56(5): 716 - 724. [Full Text] [PDF] A. De Becker, P. Van Hummelen, M. Bakkus, I. Vande Broek, J. De Wever, M. De Waele, and I. Van Riet Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3 Haematologica, April 1, 2007; 92(4): 440 - 449. [Abstract] [Full Text] [PDF] B. Ruster, S. Gottig, R. J. Ludwig, R. Bistrian, S. Muller, E. Seifried, J. Gille, and R. Henschler Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells Blood, December 1, 2006; 108(12): 3938 - 3944. [Abstract] [Full Text] [PDF] R. H. Lee, S. C. Hsu, J. Munoz, J. S. Jung, N. R. Lee, R. Pochampally, and D. J. Prockop A subset of human rapidly self-renewing marrow stromal cells preferentially engraft in mice Blood, March 1, 2006; 107(5): 2153 - 2161. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020