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 Blood, 15 July 2005, Vol. 106, No. 2, pp. 444-446.
Prepublished online as a Blood First Edition Paper on March 31, 2005; DOI 10.1182/blood-2004-11-4353.

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CHEMOKINES
Brief report

Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules

Hege S. Carlsen, Guttorm Haraldsen, Per Brandtzaeg, and Espen S. Baekkevold

From the Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute and Department of Pathology, University of Oslo, Rikshospitalet University Hospital, Norway; and the Department of Surgery, University of Oslo, Rikshospitalet University Hospital, Norway

T-cell homing to secondary lymphoid tissues generally depends on chemokine-induced firm adhesion in high endothelial venules (HEVs) and is primarily mediated through the CC chemokine receptor 7 (CCR7) on lymphocytes. The CCR7 ligand designated CCL21 is considered the most important trigger because it appears constitutively expressed by murine HEVs. Surprisingly, when we analyzed human tissues, no CCL21 mRNA could be detected in HEVs. In fact, CCL21 mRNA was only expressed in extravascular T-zone cells and lymphatics, whereas immunostaining revealed CCL21 protein within HEVs. This suggests that T-cell recruitment to human lymphoid tissues depends on the transcytosis of lymphoid chemokines through HEV cells because there is at present no evidence of alternative chemokine production in these cells that could explain the attraction of naive T lymphocytes.


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