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Blood, 15 July 2005, Vol. 106, No. 2, pp. 668-672. Prepublished online as a Blood First Edition Paper on April 5, 2005; DOI 10.1182/blood-2005-01-0140. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-01-0140v1 106/2/668    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Altieri, A. Articles by Hemminki, K. Search for Related Content PubMed PubMed Citation Articles by Altieri, A. Articles by Hemminki, K. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer Database Andrea Altieri, Justo Lorenzo Bermejo, and Kari Hemminki From the Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany; and the Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden. Non-Hodgkin lymphoma (NHL) consists of a heterogeneous group of tumors. Population-based data on the familial risk for specific histopathologic subtypes have not been established. Such data are useful for clinical counseling and for searching tumor subtypes sharing common genetic pathways. We used the Swedish Family-Cancer Database to calculate standardized incidence ratios (SIRs) for histopathology-specific subtypes of NHL in 4455 offspring with NHL whose parents or siblings were affected with different types of lymphoproliferative malignancies. A familial history of NHL significantly increased the risk for NHL (SIRparent = 1.8; SIRsibling = 1.9) and for diffuse large B-cell lymphoma (SIRparent = 2.3), follicular lymphoma (SIRsibling = 2.3), and B-cell lymphoma not otherwise specified (NOS) (SIRsibling = 3.4). For a parental history of histopathology-specific concordant cancer, the risks were significantly increased for diffuse large B-cell lymphoma (SIR = 11.8), follicular NHL (SIR = 6.1), plasma cell myeloma (SIR = 2.5), and chronic lymphocytic leukemia (SIR = 5.9). Familial clusters for NHL seemed stronger in females and in siblings. Our study provides the first quantification of the familial risks for NHL by histopathology. The present findings give evidence for a strong familial association of NHL, with little differences in the magnitude of risks for various histopathologic subtypes. The patterns of risks in parents and siblings support the hypothesis of an autosomal-dominant component for diffuse large B-cell NHL and a recessive one for follicular NHL. (Blood. 2005;106:668-672) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. L. Bermejo, J. Sundquist, and K. Hemminki Risk of Cancer among the Offspring of Women Who Experienced Parental Death during Pregnancy Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2204 - 2206. [Full Text] [PDF] K. Czene, H.-O. Adami, and E. T. Chang Sex- and Kindred-Specific Familial Risk of Non Hodgkin's Lymphoma Cancer Epidemiol. Biomarkers Prev., November 1, 2007; 16(11): 2496 - 2499. [Abstract] [Full Text] [PDF] C. F. Skibola, J. D. Curry, and A. Nieters Genetic susceptibility to lymphoma Haematologica, July 1, 2007; 92(7): 960 - 969. [Abstract] [Full Text] [PDF] S. S. Wang, S. L. Slager, P. Brennan, E. A. Holly, S. De Sanjose, L. Bernstein, P. Boffetta, J. R. Cerhan, M. Maynadie, J. J. Spinelli, et al. Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) Blood, April 15, 2007; 109(8): 3479 - 3488. [Abstract] [Full Text] [PDF] B. C.-H. Chiu, B. J. Dave, A. Blair, S. M. Gapstur, J. S. Chmiel, A. J. Fought, S. H. Zahm, and D. D. Weisenburger Cigarette Smoking, Familial Hematopoietic Cancer, Hair Dye Use, and Risk of t(14;18)-defined Subtypes of Non-Hodgkin's Lymphoma Am. J. Epidemiol., March 15, 2007; 165(6): 652 - 659. [Abstract] [Full Text] [PDF] F. Mensah, E. Willett, P Ansell, P. Adamson, and E Roman Non-Hodgkin's Lymphoma and Family History of Hematologic Malignancy Am. J. Epidemiol., January 15, 2007; 165(2): 126 - 133. [Abstract] [Full Text] [PDF] E. Negri, R. Talamini, M. Montella, L. Dal Maso, A. Crispo, M. Spina, C. La Vecchia, and S. Franceschi Family History of Hemolymphopoietic and Other Cancers and Risk of Non-Hodgkin's Lymphoma. Cancer Epidemiol. Biomarkers Prev., February 1, 2006; 15(2): 245 - 250. [Abstract] [Full Text] [PDF] E. T. Chang, K. E. Smedby, H. Hjalgrim, B. Glimelius, and H.-O. Adami Reliability of Self-Reported Family History of Cancer in a Large Case-Control Study of Lymphoma J Natl Cancer Inst, January 4, 2006; 98(1): 61 - 68. [Abstract] [Full Text] [PDF] E. T. Chang, K. E. Smedby, H. Hjalgrim, A. Porwit-MacDonald, G. Roos, B. Glimelius, and H.-O. Adami Family History of Hematopoietic Malignancy and Risk of Lymphoma J Natl Cancer Inst, October 5, 2005; 97(19): 1466 - 1474. [Abstract] [Full Text] [PDF] L. R. Goldin, O. Landgren, M. L. McMaster, G. Gridley, K. Hemminki, X. Li, L. Mellemkjaer, J. H. Olsen, and M. S. Linet Familial Aggregation and Heterogeneity of Non-Hodgkin Lymphoma in Population-Based Samples Cancer Epidemiol. Biomarkers Prev., October 1, 2005; 14(10): 2402 - 2406. [Abstract] [Full Text] [PDF] K. Hemminki, C. Eng, and B. Chen Familial Risks for Nonmedullary Thyroid Cancer J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5747 - 5753. [Abstract] [Full Text] [PDF]

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