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Blood, 15 July 2005, Vol. 106, No. 2, pp. 746-748.
Prepublished online as a Blood First Edition Paper on March 29, 2005; DOI 10.1182/blood-2004-12-4855.
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RED CELLS
Brief report
Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function
Lénaïck Détivaud,
Elizabeta Nemeth,
Karim Boudjema,
Bruno Turlin,
Marie-Bérengère Troadec,
Patricia Leroyer,
Martine Ropert,
Sylvie Jacquelinet,
Brice Courselaud,
Tomas Ganz,
Pierre Brissot, and
Olivier Loréal
From the Institut National de la Sante et de la Recherche Medicale (INSERM), U522, Rennes, France; IFR 140, Université de Rennes 1, Rennes, France; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA; and Department of Visceral Surgery, Department of Pathology, Laboratory of General Biochemistry and Enzymology, and Liver Disease Department, University Hospital Pontchaillou, Rennes, France.
Hepcidin, a key regulator of iron metabolism, is synthesized by the liver. Hepcidin binds to the iron exporter ferroportin to regulate the release of iron into plasma from macrophages, hepatocytes, and enterocytes. We analyzed liver samples from patients undergoing hepatic surgery for cancer or receiving liver transplants and analyzed correlations between clinical parameters and liver hepcidin mRNA and urinary hepcidin concentrations. Despite the many potential confounding influences, urinary hepcidin concentrations significantly correlated with hepatic hepcidin mRNA concentrations, indicating that hepcidin quantification in urine is a valid approach to evaluate hepcidin expression. Moreover, we found in humans that hepcidin levels correlated with hepatic iron stores and hemoglobin levels and may also be affected by hepatic dysfunction. (Blood. 2005;106:746-748)
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