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Blood, 15 August 2005, Vol. 106, No. 4, pp. 1495-1500. Prepublished online as a Blood First Edition Paper on May 5, 2005; DOI 10.1182/blood-2004-11-4557. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-11-4557v1 106/4/1495    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cahn, J.-Y. Articles by Socié, G. Search for Related Content PubMed PubMed Citation Articles by Cahn, J.-Y. Articles by Socié, G. Related Collections Immunobiology Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Prospective evaluation of 2 acute graft-versus-host (GVHD) grading systems: a joint Société Française de Greffe de Moëlle et Thérapie Cellulaire (SFGM-TC), Dana Farber Cancer Institute (DFCI), and International Bone Marrow Transplant Registry (IBMTR) prospective study Jean-Yves Cahn, John P. Klein, Stephanie J. Lee, Noël Milpied, Didier Blaise, Joseph H. Antin, Véronique Leblond, Norbert Ifrah, Jean-Pierre Jouet, Fausto Loberiza, Olle Ringden, A. John Barrett, Mary M. Horowitz, and Gérard Socié From the Hematology Department, Centre Hospitalo-Universitaire, Grenoble, France; International Bone Marrow Transplant Registry, Medical College of Wisconsin, Milwaukee, WI; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA; Hematology Department, Centre Hospitalo-Universitaire, Nantes, France; Hematology Department Institut Paoli-Calmettes, Marseille, France; Hematology Department, Hôpital La Pitié Salpêtrière, Paris, France; Hematology Department, Angers, France; Hematology Department, Lille, France; Huddinge University Hospital, Stockholm, Sweden; National Institutes of Health, Bethesda, MD; and Hôpital Saint-Louis, Paris, France. The most commonly used grading system for acute graft-versus-host disease (aGVHD) was introduced 30 years ago by Glucksberg; a revised system was developed by the International Bone Marrow Transplant Registry (IBMTR) in 1997. To prospectively compare the 2 classifications and to evaluate the effect of duration and severity of aGVHD on survival, we conducted a multicenter study of 607 patients receiving T-cell-replete allografts, scored weekly for aGVHD in 18 transplantation centers. Sixty-nine percent of donors were HLA-identical siblings and 28% were unrelated donors. The conditioning regimen included total body irradiation in 442 (73%) patients. The 2 classifications performed similarly in explaining variability in survival by aGVHD grade, although the Glucksberg classification predicted early survival better. There was less physician bias or error in assigning grades with the IBMTR scoring system. With either system, only the maximum observed grade had prognostic significance for survival; neither time of onset nor progression from an initially lower grade of aGVHD was associated with survival once maximum grade was considered. Regardless of scoring system, aGVHD severity accounted for only a small percentage of observed variation in survival. Validity of these results in populations receiving peripheral blood transplants or nonmyeloablative conditioning regimens remains to be tested. (Blood. 2005;106:1495-1500) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Pavletic aGVHDAI: escape from the silo Blood, July 15, 2006; 108(2): 412 - 413. [Full Text] [PDF] W. M. Leisenring, P. J. Martin, E. W. Petersdorf, A. E. Regan, N. Aboulhosn, J. M. Stern, S. N. Aker, R. C. Salazar, and G. B. McDonald An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens Blood, July 15, 2006; 108(2): 749 - 755. [Abstract] [Full Text] [PDF]

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