SEARCH:   Advanced

Blood, 15 September 2005, Vol. 106, No. 6, pp. 1992-1994. Prepublished online as a Blood First Edition Paper on June 14, 2005; DOI 10.1182/blood-2005-03-1247. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-03-1247v1 106/6/1992    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pignatelli, P. Articles by Violi, F. Search for Related Content PubMed PubMed Citation Articles by Pignatelli, P. Articles by Violi, F. Related Collections Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report Tumor necrosis factor- as trigger of platelet activation in patients with heart failure Pasquale Pignatelli, Luciano De Biase, Luisa Lenti, Giuliano Tocci, Alessandra Brunelli, Roberto Cangemi, Silvia Riondino, Susanna Grego, Massimo Volpe, and Francesco Violi From the Divisione IV Clinica Medica, Dipartimento di Medicina Sperimentale e Patologia, Policlinico Umberto I, Università "La Sapienza" di Roma; Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Università "La Sapienza" di Roma; Ospedale Sant'Andrea, Cardiologia, II Facoltà di Medicina e Chirurgia, Università "La Sapienza" di Roma. The clinical history of patients with heart failure (HF) is complicated by arterial thromboembolism. Platelet activation is reported in this population, but the underlying mechanism has not been clarified. Forty-two patients with HF scored according to New York Heart Association (NYHA) classification had higher levels of collagen-induced platelet aggregation, platelet tumor necrosis factor- (TNF-) receptor expression, and serum thromboxane B2 and higher circulating levels of TNF- than 20 healthy subjects. Coincubation of platelets from HF patients with an inhibitor of TNF- receptors significantly reduced collagen-induced platelet aggregation. In vitro study demonstrated that TNF- amplified the platelet response to collagen; this effect was inhibited by TNF- receptor antagonist and inhibitors of arachidonic acid metabolism. This study showed that TNF- behaves as a trigger of platelet activation through stimulation of the arachidonic acid pathway. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Wang, Y. Zhou, L. Meng, X. Lu, N. Ou, and X. Li Inflammatory Mediators in Chinese Patients With Congestive Heart Failure J. Clin. Pharmacol., May 1, 2009; 49(5): 591 - 599. [Abstract] [Full Text] [PDF] P. Pignatelli, R. Cangemi, A. Celestini, R. Carnevale, L. Polimeni, A. Martini, D. Ferro, L. Loffredo, and F. Violi Tumour necrosis factor {alpha} upregulates platelet CD40L in patients with heart failure Cardiovasc Res, June 1, 2008; 78(3): 515 - 522. [Abstract] [Full Text] [PDF] L. H. Opie and S. Lecour The red wine hypothesis: from concepts to protective signalling molecules Eur. Heart J., July 2, 2007; 28(14): 1683 - 1693. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020