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Blood, 15 October 2005, Vol. 106, No. 8, pp. 2700-2709. Prepublished online as a Blood First Edition Paper on May 3, 2005; DOI 10.1182/blood-2005-01-0330. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-01-0330v1 106/8/2700    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Statkute, L. Articles by Burt, R. K. Search for Related Content PubMed PubMed Citation Articles by Statkute, L. Articles by Burt, R. K. Related Collections Hemostasis, Thrombosis, and Vascular Biology Immunobiology Transplantation Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Antiphospholipid syndrome in patients with systemic lupus erythematosus treated by autologous hematopoietic stem cell transplantation Laisvyde Statkute, Ann Traynor, Yu Oyama, Kim Yaung, Larissa Verda, Nela Krosnjar, and Richard K. Burt From the Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Systemic lupus erythematosus (SLE) is the most common disease associated with antiphospholipid syndrome (APS). We, therefore, evaluated 46 patients with refractory SLE treated by autologous hematopoietic stem cell transplantation (HSCT) for a history of APS prior to transplantation. The prevalence of SLE-related APS in our patient population was 61% (28 of 46 patients with refractory SLE). Nineteen of 28 patients with APS had lupus anticoagulant (LA) or high titers of anticardiolipin antibodies (ACLAs), either immunoglobulin (Ig)G or IgM, when evaluated at study entry. Six of 8 evaluable LA+ patients became and remained LA–; 5 of 7 initially ACLA IgG+ patients and 9 of 11 ACLA IgM+ patients demonstrated normalization of ACLA titers when followed after HSCT. Eighteen of 22 patients refractory to chronic anticoagulation discontinued anticoagulation therapy a median of 4 months after transplantation; 78% of them remained free of thrombotic events and in complete SLE remission for up to 78 months (median, 15 months) after HSCT. There was no treatment-related mortality. Autologous HSCT may be performed safely in patients with APS and appears to be effective therapy for eliminating ALPAs and preventing thrombotic complications in patients with SLE. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Transplantation for SLE? Steven Z. Pavletic Blood 2005 106: 2597. [Full Text] [PDF] This article has been cited by other articles: F. Braiteh, S. R. Hymes, S. A. Giralt, and R. Jones Complete Remission of Psoriasis After Autologous Hematopoietic Stem-Cell Transplantation for Multiple Myeloma J. Clin. Oncol., September 20, 2008; 26(27): 4511 - 4513. [Full Text] [PDF] A Ruckert, H Glimm, M Lubbert, and C Grullich Successful treatment of life-threatening Evans syndrome due to antiphospholipid antibody syndrome by rituximab-based regimen: a case with long-term follow-up Lupus, August 1, 2008; 17(8): 757 - 760. [Abstract] [PDF] D. A. Garcia, M. A. Khamashta, and M. A. Crowther How we diagnose and treat thrombotic manifestations of the antiphospholipid syndrome: a case-based review Blood, November 1, 2007; 110(9): 3122 - 3127. [Abstract] [Full Text] [PDF] G. S. Hill and D. Nochy Antiphospholipid Syndrome in Systemic Lupus Erythematosus J. Am. Soc. Nephrol., September 1, 2007; 18(9): 2461 - 2464. [Abstract] [Full Text] [PDF] R. K. Burt, A. Traynor, L. Statkute, W. G. Barr, R. Rosa, J. Schroeder, L. Verda, N. Krosnjar, K. Quigley, K. Yaung, et al. Nonmyeloablative Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus JAMA, February 1, 2006; 295(5): 527 - 535. [Abstract] [Full Text] [PDF]

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