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Blood, 1 November 2005, Vol. 106, No. 9, pp. 2969-2976. Prepublished online as a Blood First Edition Paper on July 5, 2005; DOI 10.1182/blood-2004-09-3544. This Article Full Text Full Text (PDF) All Versions of this Article: 2004-09-3544v1 106/9/2969    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Crawley, C. Articles by Apperley, J. F. Search for Related Content PubMed PubMed Citation Articles by Crawley, C. Articles by Apperley, J. F. Related Collections Neoplasia Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL TRIALS AND OBSERVATIONS Outcomes of reduced-intensity transplantation for chronic myeloid leukemia: an analysis of prognostic factors from the Chronic Leukemia Working Party of the EBMT Charles Crawley, Richard Szydlo, Marc Lalancette, Andrea Bacigalupo, Andrzej Lange, Mats Brune, Gunnar Juliusson, Arnon Nagler, Alois Gratwohl, Jakob Passweg, Mieczysaw Komarnicki, Antonin Vitek, Jiri Mayer, Axel Zander, Jorge Sierra, Alessandro Rambaldi, Olle Ringden, Dietger Niederwieser, Jane F. Apperley, for the Chronic Leukemia Working Party of the EBMT From Addenbrookes Hospital, Cambridge, United Kingdom; Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom; the Centre Hospitalier Universitaire de Quebec (CHUQ), L'Hôtel-Dieu, Quebec, Canada; the Ospedale San Martino, Genova, Italy; the Lower Silesian Centre for Cellular Transplantation, Wroclaw, Poland; the Sahlgrenska University Hospital, Goeteborg, Sweden; the University Hospital, Lund, Sweden; the Chaim Sheba Medical Center, Tel-Hashomer, Israel; the University Hospital, Basel, Switzerland; the University of Medical Sciences, Poznan, Poland; the Institute of Hematology and Blood Transfusion, Prague, Czech Republic; the University Hospital Brno, Brno, Czech Republic; the University Hospital Eppendorf, Hamburg, Germany; the Hospital Santa Creu I Sant Pau, Barcelona, Spain; the Ospedale Bergamo, Bergamo, Italy; the Huddinge University Hospital, Huddinge, Sweden; and the University of Leipzig, Leipzig, Germany. This study reports outcomes of allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning (RIC) in 186 patients with chronic myeloid leukemia (CML) from the European Group for Blood and Marrow Transplantation (EBMT). The median age was 50 years, and 64% were in first chronic phase (CP1), CP2 13%, accelerated phase 17%, and blast crises 6%. The median EBMT transplant score was 3. The day 100 transplantation-related mortality (TRM) was 6.1% (confidence interval [CI], 3.4%-11%) but rose to 23.3% (CI, 14%-27%) at 2 years. Fludarabine, busulfan, and antithymocyte globulin (Fd/Bu/ATG) was associated with the lowest TRM of 11.6% (CI, 4.7%-11%) at 1 year. Acute graft-versus-host disease (GvHD) grade II to IV occurred in 32% and chronic GvHD in 43% (extensive in 24%). ATG was associated with a lower incidence of chronic GvHD (cGvHD). The overall survival (OS) and progression-free survival (PFS) at 3 years were 58% (CI, 50%-66%) and 37% (CI, 30%-45%), respectively. Adverse OS was associated with advanced disease (relative risk [RR], 3.4). PFS was inferior in advanced disease (RR, 2.7) and a trend to improved outcomes with Fd/Bu/ATG (RR, 0.58). RIC allografts are feasible in CML in first or second CP. Since no other RIC regimen demonstrated superiority, Fd/Bu/ATG should be considered as baseline in future prospective trials. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. Ayuk, J. A. Perez-Simon, A. Shimoni, A. Sureda, T. Zabelina, R. Schwerdtfeger, R. Martino, H. G. Sayer, A. Alegre, J.-J. Lahuerta, et al. Clinical impact of human Jurkat T-cell-line-derived antithymocyte globulin in multiple myeloma patients undergoing allogeneic stem cell transplantation Haematologica, September 1, 2008; 93(9): 1343 - 1350. [Abstract] [Full Text] [PDF] N. B. Heaney, M. Copland, K. Stewart, J. Godden, A. N. Parker, I. G. McQuaker, G. M. Smith, C. Crawley, P. Shepherd, and T. 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