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Blood, 1 November 2005, Vol. 106, No. 9, pp. 3234-3241. Prepublished online as a Blood First Edition Paper on July 7, 2005; DOI 10.1182/blood-2005-03-1288. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-03-1288v1 106/9/3234    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cao, C. Articles by Zhang, L. Search for Related Content PubMed PubMed Citation Articles by Cao, C. Articles by Zhang, L. Related Collections Immunobiology Phagocytes Cell Adhesion and Motility Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PHAGOCYTES A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics Chunzhang Cao, Daniel A. Lawrence, Dudley K. Strickland, and Li Zhang From the Department of Physiology, University of Maryland School of Medicine; and the Department of Surgery, University of Maryland School of Medicine, Rockville, MD. In response to injury, monocytes migrate to the site of inflammation, where they differentiate into macrophages and participate in various biologic processes. However, their fate during the resolution of acute inflammation is not fully understood. Here, we show that inflammatory macrophages do not die locally by apoptosis; rather, they migrate across the peritoneal mesothelium to the lymphatics, through which they further migrate to the lymph nodes and to the blood circulation. Macrophage efflux is enhanced considerably on cell activation, and such accelerated macrophage migration is dependent specifically on integrin Mac-1, and can be blocked by addition of its antagonist. Thus, genetic inactivation of Mac-1 in mice inhibits the accelerated macrophage efflux from the inflammatory site to the lymphatics, but it does not compromise the accumulation of blood monocytes into the inflammatory site. Together, our study demonstrates that Mac-1 is involved specifically in the efflux of activated macrophages to the lymphatics, suggesting that Mac-1 may play an important role in the removal of local inflammatory macrophages and in their subsequent migration to the lymph nodes, a process that is critical to the development of the adaptive immunity. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Mac-1 mediates migration to lymph nodes Joseph P. Mizgerd Blood 2005 106: 2927-2928. [Full Text] [PDF] This article has been cited by other articles: C. Kim, S. Wilcox-Adelman, Y. Sano, W.-J. Tang, R. J. Collier, and J. M. Park From the Cover: Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus PNAS, April 22, 2008; 105(16): 6150 - 6155. [Abstract] [Full Text] [PDF] B. E. Potts, M. L. Hart, L. L. Snyder, D. Boyle, D. A. Mosier, and S. K. Chapes Differentiation of C2D Macrophage Cells after Adoptive Transfer Clin. Vaccine Immunol., February 1, 2008; 15(2): 243 - 252. [Abstract] [Full Text] [PDF] J. Y. Park, M. Amin Arnaout, and V. Gupta A Simple, No-Wash Cell Adhesion-Based High-Throughput Assay for the Discovery of Small-Molecule Regulators of the Integrin CD11b/CD18 J Biomol Screen, April 1, 2007; 12(3): 406 - 417. [Abstract] [PDF]

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