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Blood, 1 January 2006, Vol. 107, No. 1, pp. 187-189. Prepublished online as a Blood First Edition Paper on August 25, 2005; DOI 10.1182/blood-2005-07-3059. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-07-3059v1 107/1/187    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zimring, J. C. Articles by Horan, J. T. Search for Related Content PubMed PubMed Citation Articles by Zimring, J. C. Articles by Horan, J. T. Related Collections Immunobiology Transfusion Medicine Brief Reports Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Brief report Immunization to minor histocompatibility antigens on transfused RBCs through crosspriming into recipient MHC class I pathways James C. Zimring, Gregory A. Hair, Seema S. Deshpande, and John T. Horan From the Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA; and the Department of Pediatrics, Emory University School of Medicine, Aflac Center for Pediatric Blood and Cancer Disorders, Atlanta, GA. Increased rates of graft rejection after bone marrow transplantation (BMT) are observed in patients whose illnesses— such as sickle cell disease, thalassemia, and aplastic anemia—necessitate chronic transfusion before BMT. Because BM transplants in these patients are routinely HLA matched, any immunization responsible for increased rejection is likely against minor histocompatibility antigens (mHAs). It has been assumed that contaminating leukocytes in red blood cell (RBC) units are the main sources of immunization to mHAs. However, in this report, we demonstrate that antigens on donor RBCs are presented in the major histocompatibility complex (MHC) class I pathway of recipient antigen-presenting cells, resulting in activation and expansion of recipient CD8+ T cells specific for donor mHAs. Given that human hematopoietic progenitor cells express many of the known mHAs, this observation provides a mechanism by which chronic transfusion of even stringently leukoreduced RBCs may result in sufficient mHA immunization to increase the frequency of BMT rejection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Transfusion tickles T cells through cross-priming James D. Gorham Blood 2006 107: 6-7. [Full Text] [PDF] This article has been cited by other articles: M. Desmarets, C. M. Cadwell, K. R. Peterson, R. Neades, and J. C. Zimring Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model Blood, September 10, 2009; 114(11): 2315 - 2322. [Abstract] [Full Text] [PDF]

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