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Blood, 1 January 2006, Vol. 107, No. 1, pp. 213-221.
Prepublished online as a Blood First Edition Paper on September 13, 2005; DOI 10.1182/blood-2005-06-2273.
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NEOPLASIA
Transmembrane adaptor molecules: a new category of lymphoid-cell markers
Sara Tedoldi,
Jennifer C. Paterson,
Martin-Leo Hansmann,
Yasodha Natkunam,
Thomas Rüdiger,
Pavla Angelisova,
Ming Q. Du,
Helen Roberton,
Giovanna Roncador,
Lydia Sanchez,
Michela Pozzobon,
Noraidah Masir,
Richard Barry,
Stefano Pileri,
David Y. Mason,
Teresa Marafioti, and
Václav Horejsí
From the Leukaemia Research Fund Immunodiagnostics Unit, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom; Senckenberg Pathology Institute, Johann Wolfgang Goethe-University Clinic Frankfurt AM Main, Frankfurt AM Main, Germany; Department of Pathology, Stanford University School of Medicine, Stanford, CA; Institute of Pathology, University of Würzburg, Würzburg, Germany; Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom; National Center for the Investigation of Oncology, Monoclonal Antibodies Unit, Biotechnology Program, Madrid, Spain; and Department of Pathology and Unit of Haematopathology, "L & A Seragnoli" Institute of Haematology, University of Bologna, Bologna, Italy.
Transmembrane adaptor proteins (of which 7 have been identified so far) are involved in receptor signaling in immune cells. They have only a short extracellular region, with most of the molecule comprising a substantial intracytoplasmic region carrying multiple tyrosine residues that can be phosphorylated by Src- or Syk-family kinases. In this paper, we report an immunohistologic study of 6 of these molecules in normal and neoplastic human tissue sections and show that they are restricted to subpopulations of lymphoid cells, being present in either T cells (LAT, LIME, and TRIM), B cells (NTAL), or subsets of both cell types (PAG and SIT). Their expression in neoplastic lymphoid cells broadly reflects that of normal lymphoid tissue, including the positivity of plasma cells and myeloma/plasmacytoma for LIME, NTAL, PAG, and SIT. However, this study also revealed some reactions that may be of diagnostic/prognostic value. For example, lymphocytic lymphoma and mantle-cell lymphoma showed similar profiles but differed clearly from follicle-center lymphoma, whereas PAG tended to be selectively expressed in germinal center-derived subsets of diffuse large B-cell lymphoma. These molecules represent a potentially important addition to the panel of immunophenotypic markers detectable in routine biopsies that can be used in hematopathologic studies.
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