Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 1 January 2006, Vol. 107, No. 1, pp. 355-357.
Prepublished online as a Blood First Edition Paper on September 22, 2005; DOI 10.1182/blood-2005-03-1231.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
2005-03-1231v1
107/1/355    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Borgna-Pignatti, C.
Right arrow Articles by Volpato, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Borgna-Pignatti, C.
Right arrow Articles by Volpato, S.
Related Collections
Right arrow Red Cells
Right arrow Brief Reports
Right arrow Clinical Trials and Observations
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

RED CELLS
Brief report

Seasonal variation of pretransfusion hemoglobin levels in patients with thalassemia major

Caterina Borgna-Pignatti, Mariela Ventola, David Friedman, Alan R. Cohen, Raffaella Origa, Renzo Galanello, Robert Lindeman, Sally Francis, Roberto Reverberi, and Stefano Volpato

From the Departments of Clinical and Experimental Medicine-Pediatrics, University of Ferrara, Ferrara, Italy; the Transfusion Service, Arcispedale Sant'Anna, Ferrara, Italy; the Ospedale Microcitemico and the Department of Biomedical Sciences and Biotechnology, University of Cagliari, Cagliari, Italy; the Prince of Wales Hospital, Randwick, NSW Australia; and the Division of Hematology, the Children's Hospital of Philadelphia, Philadelphia, PA.

Patients with thalassemia major often report that they do not maintain their usual pretransfusion hemoglobin concentration during the summer season. We collected 3977 pretransfusion hemoglobin values, amount of blood transfused, and intertransfusion intervals for 94 patients with thalassemia major from 4 centers worldwide. We also assessed the hematocrits of blood donors, the hemoglobin content of units transfused in one center, and the local mean monthly temperatures during the periods of data collection. Pretransfusion hemoglobin levels were significantly lower during the summer in all centers except the one center where monthly temperatures have the least variation throughout the year. A similar relationship to temperature was observed for the hematocrits of blood donors and the hemoglobin content of donor units. This study confirms that pretransfusion hemoglobin levels in patients with thalassemia major are lower in the summertime. Possible mechanisms include expansion of plasma volume with resultant hemodilution in the patient and lower hemoglobin content in donor blood.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020