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 Blood, 1 January 2006, Vol. 107, No. 1, pp. 355-357.
Prepublished online as a Blood First Edition Paper on September 22, 2005; DOI 10.1182/blood-2005-03-1231.

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RED CELLS
Brief report

Seasonal variation of pretransfusion hemoglobin levels in patients with thalassemia major

Caterina Borgna-Pignatti, Mariela Ventola, David Friedman, Alan R. Cohen, Raffaella Origa, Renzo Galanello, Robert Lindeman, Sally Francis, Roberto Reverberi, and Stefano Volpato

From the Departments of Clinical and Experimental Medicine-Pediatrics, University of Ferrara, Ferrara, Italy; the Transfusion Service, Arcispedale Sant'Anna, Ferrara, Italy; the Ospedale Microcitemico and the Department of Biomedical Sciences and Biotechnology, University of Cagliari, Cagliari, Italy; the Prince of Wales Hospital, Randwick, NSW Australia; and the Division of Hematology, the Children's Hospital of Philadelphia, Philadelphia, PA.

Patients with thalassemia major often report that they do not maintain their usual pretransfusion hemoglobin concentration during the summer season. We collected 3977 pretransfusion hemoglobin values, amount of blood transfused, and intertransfusion intervals for 94 patients with thalassemia major from 4 centers worldwide. We also assessed the hematocrits of blood donors, the hemoglobin content of units transfused in one center, and the local mean monthly temperatures during the periods of data collection. Pretransfusion hemoglobin levels were significantly lower during the summer in all centers except the one center where monthly temperatures have the least variation throughout the year. A similar relationship to temperature was observed for the hematocrits of blood donors and the hemoglobin content of donor units. This study confirms that pretransfusion hemoglobin levels in patients with thalassemia major are lower in the summertime. Possible mechanisms include expansion of plasma volume with resultant hemodilution in the patient and lower hemoglobin content in donor blood.


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