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Blood, 1 June 2006, Vol. 107, No. 11, pp. 4417-4423. Prepublished online as a Blood First Edition Paper on February 14, 2006; DOI 10.1182/blood-2005-10-4129. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-10-4129v1 107/11/4417    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mennechet, F. J. D. Articles by Uzé, G. Search for Related Content PubMed PubMed Citation Articles by Mennechet, F. J. D. Articles by Uzé, G. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Interferon-–treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells Franck J. D. Mennechet, and Gilles Uzé From Centre National de la Recherche Scientifique (CNRS) Unité mixte de recherche (UMR) 5124, University of Montpellier, France. The interferons (IFN-s), also known as IL-28 and IL-29, are coexpressed with IFN- after Toll-like–receptor (TLR) stimulation in human monocyte–derived dendritic cells (DCs). IFN- shares with type I IFNs an intracellular signaling pathway that drives the expression of a common set of genes. However, IFN- signaling is initiated through a membrane receptor system distinct from that of type I IFNs. Because IFNs produced by DCs in response to TLR stimulation are critical in the differentiation and maturation of DCs, we sought to investigate whether IFN- exhibits specific effects on DC differentiation. In this work, we show that DCs acquire IFN- responsiveness through the expression of the specific IFN- receptor chain during their differentiation from monocytes. IFN-–treated DCs express high levels of major histocompatibility complex class I (MHC class I) and MHC class II but low levels of costimulatory molecules. However, they express CCR7 and acquire the ability to migrate to lymph nodes when intravenously injected into SCID/Bg mice. In mixed lymphocyte reaction (MLR) cultures, IFN-–treated DCs specifically induced IL-2–dependent proliferation of a CD4+CD25+Foxp3+ T-cell subset with contact-dependent suppressive activity on T-cell proliferation initiated by fully mature DCs. IFN-s are thus able to generate tolerogenic DCs, an activity that could thwart IFN- functions. 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