|
|
Blood, 1 June 2006, Vol. 107, No. 11, pp. 4475-4483.
Prepublished online as a Blood First Edition Paper on February 7, 2006; DOI 10.1182/blood-2005-10-3994.
 Previous Article | Table of Contents | Next Article 
IMMUNOBIOLOGY
Cytokine-induced IL-10–secreting CD8 T cells represent a phenotypically distinct suppressor T-cell lineage
Alistair Noble,
Angela Giorgini, and
Jamie A. Leggat
From the Medical Research Council (MRC) and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, United Kingdom.
Populations of regulatory T cells (Tregs) control autoimmune and allergic immunopathology induced by self or foreign antigens. Several types of CD4+ MHC class II–restricted Treg populations have been characterized, but the biology of CD8+, MHC class I–restricted Tregs is less understood. We show here that CD8+ Tregs are rapidly generated in the presence of IL-4 and IL-12, produce IL-10, and exhibit a unique cell-surface phenotype with coexpression of activation and naive cell-associated markers. They block activation of naive or effector T cells and suppress IgG/IgE antibody responses and graft-versus-host disease in vivo. Suppression is dependent on cell contact and mediated by direct T-cell–T-cell interaction that antagonizes T-cell–receptor (TCR) signals. The data establish the existence of a CD8 T-cell suppressor effector subset distinct in both phenotype and function from T cytotoxic 1 (Tc1) and Tc2 cells. Production of such CD8 Tregs has potential for cell-based therapy of CD4 or CD8 T-cell–mediated disease.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Article in Blood Online:
-
A tale of two T cells: suppressor CD8 T cells recalled to life
- Edmund K. Waller
Blood 2006 107: 4203-4204.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
M. Rifa'i, Z. Shi, S.-Y. Zhang, Y. H. Lee, H. Shiku, K.-i. Isobe, and H. Suzuki
CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-{alpha}{beta}TCR interaction and become IL-10-producing active regulatory cells
Int. Immunol.,
July 1, 2008;
20(7):
937 - 947.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Fang, G. C. Sharp, and H. Braley-Mullen
Interleukin-10 Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis
Am. J. Pathol.,
June 1, 2008;
172(6):
1591 - 1602.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Giorgini and A. Noble
Blockade of chronic graft-versus-host disease by alloantigen-induced CD4+CD25+Foxp3+ regulatory T cells in nonlymphopenic hosts
J. Leukoc. Biol.,
November 1, 2007;
82(5):
1053 - 1061.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Billerbeck, H. E. Blum, and R. Thimme
Parallel Expansion of Human Virus-Specific FoxP3- Effector Memory and De Novo-Generated FoxP3+ Regulatory CD8+ T Cells upon Antigen Recognition In Vitro
J. Immunol.,
July 15, 2007;
179(2):
1039 - 1048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. F. Anderson, M. Oukka, V. J. Kuchroo, and D. Sacks
CD4+CD25-Foxp3- Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
J. Exp. Med.,
February 19, 2007;
204(2):
285 - 297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. d. l. L. Garcia-Hernandez, A. Gray, B. Hubby, and W. M. Kast
In vivo Effects of Vaccination with Six-Transmembrane Epithelial Antigen of the Prostate: A Candidate Antigen for Treating Prostate Cancer
Cancer Res.,
February 1, 2007;
67(3):
1344 - 1351.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
