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Blood, 15 March 2006, Vol. 107, No. 6, pp. 2453-2460. Prepublished online as a Blood First Edition Paper on November 22, 2005; DOI 10.1182/blood-2005-07-2831. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-07-2831v1 107/6/2453    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Alpdogan, O. Articles by van den Brink, M. R. M. Search for Related Content PubMed PubMed Citation Articles by Alpdogan, O. Articles by van den Brink, M. R. M. Related Collections Immunobiology Signal Transduction Immunotherapy Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration Önder Alpdogan, Vanessa M. Hubbard, Odette M. Smith, Neel Patel, Sydney Lu, Gabrielle L. Goldberg, Daniel H. Gray, Jared Feinman, Adam A. Kochman, Jeffrey M. Eng, David Suh, Stephanie J. Muriglan, Richard L. Boyd, and Marcel R. M. van den Brink From the Departments of Medicine and Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY; and the Department of Pathology and Immunology, Monash University Medical School, Melbourne, Victoria, Australia. Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family that mediates epithelial cell proliferation and differentiation in a variety of tissues, including the thymus. We studied the role of KGF in T-cell development with KGF-/- mice and demonstrated that thymic cellularity and the distribution of thymocyte subsets among KGF-/-, wildtype (WT), and KGF+/- mice were similar. However, KGF-/- mice are more vulnerable to sublethal irradiation (450 cGy), and a significant decrease was found in thymic cellularity after irradiation. Defective thymopoiesis and peripheral T-cell reconstitution were found in KGF-/- recipients of syngeneic or allogeneic bone marrow transplant, but using KGF-/- mice as a donor did not affect T-cell development after transplantation. Despite causing an early developmental block in the thymus, administration of KGF to young and old mice enhanced thymopoiesis. Exogenous KGF also accelerated thymic recovery after irradiation, cyclophosphamide, and dexamethasone treatment. Finally, we found that administering KGF before bone marrow transplantation (BMT) resulted in enhanced thymopoiesis and peripheral T-cell numbers in middle-aged recipients of an allogeneic BM transplant. We conclude that KGF plays a critical role in postnatal thymic regeneration and may be useful in treating immune deficiency conditions. (Blood. 2006;107:2453-2460) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Odaka Localization of Mesenchymal Cells in Adult Mouse Thymus: Their Abnormal Distribution in Mice With Disorganization of Thymic Medullary Epithelium J. Histochem. Cytochem., April 1, 2009; 57(4): 373 - 382. [Abstract] [Full Text] [PDF] R. R. Jenq, C. G. King, C. Volk, D. Suh, O. M. Smith, U. K. Rao, N. L. Yim, A. M. Holland, S. X. Lu, J. L. Zakrzewski, et al. 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