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Blood, 15 March 2006, Vol. 107, No. 6, pp. 2536-2539. Prepublished online as a Blood First Edition Paper on November 1, 2005; DOI 10.1182/blood-2005-07-2694. This Article Full Text Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-07-2694v1 107/6/2536    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Janz, M. Articles by Bargou, R. C. Search for Related Content PubMed PubMed Citation Articles by Janz, M. Articles by Bargou, R. C. Related Collections Neoplasia Apoptosis Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief report Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells Martin Janz, Michael Hummel, Matthias Truss, Brigitte Wollert-Wulf, Stephan Mathas, Korinna Jöhrens, Christian Hagemeier, Kurt Bommert, Harald Stein, Bernd Dörken, and Ralf C. Bargou From the Max Delbrück Center for Molecular Medicine; the Department of Hematology, Oncology, and Tumorimmunology, Charité, University Medicine Berlin, Campus Buch and Campus Virchow; the Institute of Pathology, Charité, University Medicine Berlin, Campus Benjamin Franklin; the Department of Pediatrics, Laboratory for Molecular Biology, Charité, University Medicine Berlin, Berlin, Germany; and the Department of Internal Medicine II, Division of Hematology and Oncology, University Hospital Würzburg, Würzburg, Germany. Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) display unique characteristics that discriminate cHL from other B-cell lymphomas and normal B cells. Therefore, comparative gene expression profiling of Hodgkin and non-Hodgkin B cells could lead to the identification of candidate genes that are critical for the pathogenesis of cHL. We performed microarray analysis of Hodgkin and non-Hodgkin cell lines and identified activating transcription factor 3 (ATF3), a member of the cyclic AMP response element binding protein (CREB)/ATF family, as a differentially expressed candidate gene. Extensive analysis of a large panel of cell lines, primary tumor samples, and normal tissues revealed that high expression of ATF3 is found in nearly all cases of cHL and is almost exclusively restricted to it. Selective knock-down of ATF3 by RNA interference suppressed proliferation and strongly reduced viability of Hodgkin cells. Thus, overexpression of ATF3 is a molecular hallmark of cHL that contributes to the malignant growth of HRS cells. (Blood. 2006;107:2536-2539) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Hirsch, M. Hummel, S. Bentink, F. Fouladi, R. Spang, R. Zollinger, H. Stein, and H. Durkop CD30-Induced Signaling Is Absent in Hodgkin's Cells but Present in Anaplastic Large Cell Lymphoma Cells Am. J. Pathol., February 1, 2008; 172(2): 510 - 520. [Abstract] [Full Text] [PDF] S. Bandyopadhyay, Y. Wang, R. Zhan, S. K. Pai, M. Watabe, M. Iiizumi, E. Furuta, S. Mohinta, W. Liu, S. Hirota, et al. The Tumor Metastasis Suppressor Gene Drg-1 Down-regulates the Expression of Activating Transcription Factor 3 in Prostate Cancer Cancer Res., December 15, 2006; 66(24): 11983 - 11990. [Abstract] [Full Text] [PDF]

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