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 Blood, 1 April 2006, Vol. 107, No. 7, pp. 2605-2612.
Prepublished online as a Blood First Edition Paper on December 6, 2005; DOI 10.1182/blood-2005-07-2991.

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REVIEW IN TRANSLATIONAL HEMATOLOGY

Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells

M. William Lensch, and George Q. Daley

From the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA; Division of Hematology/Oncology, Children's Hospital Boston, Boston, MA; Harvard Stem Cell Institute, Cambridge, MA; Division of Hematology/Oncology, Brigham and Women's Hospital, Boston, MA; and Dana-Farber Cancer Institute, Boston, MA.

Abstract

Our considerable wealth of data concerning hematologic processes has come despite difficulties working with stem and progenitor cells in vitro and their propensity to differentiate. Key methodologies that have sought to overcome such limitations include transgenic/knock-out animals and in vitro studies using murine embryonic stem cells, because both permit investigation of the formation of hematopoietic tissue from nonhematopoietic precursors. Although there have been many successful studies in model animals for understanding hematopoietic-cell development, differences between lower vertebrates and humans have left gaps in our understanding. Clearly, human-specific strategies to study the onset of hematopoiesis, particularly the earliest events leading to the specification of both normal and abnormal hematopoietic tissue, could bring an investigational renaissance. The recent availability of human embryonic stem (hES) cells suggests that such a system is now at hand. This review highlights the potential of hES cells to model human hematologic processes in vitro with an emphasis on disease targets.


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