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Blood, 1 April 2006, Vol. 107, No. 7, pp. 2774-2776. Prepublished online as a Blood First Edition Paper on December 8, 2005; DOI 10.1182/blood-2005-08-3210. This Article Full Text Full Text (PDF) Supplemental Figures All Versions of this Article: 2005-08-3210v1 107/7/2774    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Duda, D. G. Articles by Jain, R. K. Search for Related Content PubMed PubMed Citation Articles by Duda, D. G. Articles by Jain, R. K. Related Collections Hemostasis, Thrombosis, and Vascular Biology Neoplasia Stem Cells in Hematology Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report Evidence for incorporation of bone marrow–derived endothelial cells into perfused blood vessels in tumors Dan G. Duda, Kenneth S. Cohen, Sergey V. Kozin, Jean Y. Perentes, Dai Fukumura, David T. Scadden, and Rakesh K. Jain From the E. L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, and the Center for Regenerative Medicine, Massachusetts General Hospital, Boston; and the Department of Thoracic Surgery, University Hospital of Lausanne (CHUV), Switzerland. Recent studies have demonstrated that the cellular contribution of the bone marrow to tumor neovascularization is highly complex. In this context, the extent to which bone marrow–derived cells incorporate as bona fide endothelial (nonhematopoietic) cells into perfused tumor vessels, or any new vessels formed postnatally (vasculogenesis), is unclear. To this end, we developed models to characterize local vessel–derived and bone marrow–derived endothelial cells (BMD-ECs). Then, we characterized the BMD-ECs based on a set of endothelial markers and morphology. Finally, we quantified their contribution to perfused blood vessels in tumors using transplanted as well as spontaneous primary and metastatic tumor models. We demonstrate that BMD-ECs incorporate in perfused tumor vessels, and that this contribution varies with organ site and mouse strain. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. J. Madlambayan, J. M. Butler, K. Hosaka, M. Jorgensen, D. Fu, S. M. Guthrie, A. K. Shenoy, A. Brank, K. J. Russell, J. Otero, et al. 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