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Blood, 1 April 2006, Vol. 107, No. 7, pp. 2797-2805. Prepublished online as a Blood First Edition Paper on December 15, 2005; DOI 10.1182/blood-2005-08-3103. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: 2005-08-3103v1 107/7/2797    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Matsuda, J. L. Articles by Gapin, L. Search for Related Content PubMed PubMed Citation Articles by Matsuda, J. L. Articles by Gapin, L. Related Collections Immunobiology Apoptosis Cell Adhesion and Motility Signal Transduction Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY T-bet concomitantly controls migration, survival, and effector functions during the development of V14i NKT cells Jennifer L. Matsuda, Qianjun Zhang, Rachel Ndonye, Stewart K. Richardson, Amy R. Howell, and Laurent Gapin From the Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Science Center, Denver; and Department of Chemistry, University of Connecticut, Storrs. V14i natural killer T (NKT)–cell function has been implicated in a number of disease conditions. The molecular events that drive V14i NKT-cell development remain elusive. We recently showed that T-bet is required for the terminal maturation of these cells. Here we identify some of the genetic targets of T-bet during V14i NKT-cell lineage development. Microarray gene-expression analyses on developing V14i NKT cells were performed and provide a molecular framework to study these maturation events. In vitro ectopic expression of T-bet in immature V14i NKT cells, which do not yet express T-bet, was sufficient to promote V14i NKT-cell maturation, driving the expression of multiple genes, including those that participate in migration, survival, and effector functions. By regulating the expression of T-helper 1 (Th1)–associated cytokines, chemokines, chemokine receptors, and molecules involved in cytolysis, T-bet defines the unique lineage attributes of mature V14i NKT cells and acts to link these attributes to a developmental process. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: V. J. Lawson, D. Maurice, J. D. Silk, V. Cerundolo, and K. 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