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Blood, 1 April 2006, Vol. 107, No. 7, pp. 2904-2911. Prepublished online as a Blood First Edition Paper on December 8, 2005; DOI 10.1182/blood-2005-07-2615. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: 2005-07-2615v1 107/7/2904    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Buhl, A. M. Articles by Leffers, H. Search for Related Content PubMed PubMed Citation Articles by Buhl, A. M. Articles by Leffers, H. Related Collections Oncogenes and Tumor Suppressors Immunobiology Neoplasia Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia Anne Mette Buhl, Jesper Jurlander, Flemming S. Jørgensen, Anne Marie Ottesen, Jack B. Cowland, Lise Mette Gjerdrum, Brian V. Hansen, and Henrik Leffers From The Leukemia Laboratory, the Granulocyte Laboratory, Department of Hematology, Department of Pathology, and The University Department of Growth and Reproduction, Rigshospitalet; and the Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Copenhagen, DK. The pathogenesis of chronic lymphocytic leukemia (CLL) is unknown but may involve aberrant activation of signaling pathways. Somatic hypermutations in rearranged immunoglobulin heavy-chain (IgVH) genes allow a division of CLL patients into 2 categories: mutated IgVH genes are associated with an indolent disease, whereas unmutated IgVH genes define an aggressive form. Using differential display to compare gene expression in CLL cells with and without IgVH hypermutations, we identified a novel gene, CLL up-regulated gene 1 (CLLU1), that was highly up-regulated in CLL cells without IgVH hypermutations. CLLU1 mapped to chromosome 12q22, within a cluster of genes that are active in germinal center B cells. However, appreciable levels of CLLU1 were detectable only in CLL cells and not in a panel of normal tissue extracts or in any other tested hematologic malignancy. High expression of CLLU1 in CLL samples occurred irrespective of trisomy 12 or large chromosomal rearrangements. CLLU1 encodes 6 mRNAs with no sequence homology to any known gene, and most transcripts appear to be noncoding. Two transcripts, however, potentially encode a peptide with remarkable structural similarity to human interleukin 4. These data, in particular the unique and restricted expression pattern, suggest that CLLU1 is the first disease-specific gene identified in CLL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: A novel gene for an old disease Federico Caligaris-Cappio Blood 2006 107: 2594. [Full Text] [PDF] This article has been cited by other articles: P. Josefsson, C. H. Geisler, H. Leffers, J. H. Petersen, M. K. Andersen, J. Jurlander, and A. M. Buhl CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemia Blood, June 1, 2007; 109(11): 4973 - 4979. [Abstract] [Full Text] [PDF]

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