SEARCH:   Advanced

Blood, 1 May 2006, Vol. 107, No. 9, pp. 3761-3763. Prepublished online as a Blood First Edition Paper on January 10, 2006; DOI 10.1182/blood-2005-06-2235. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-06-2235v1 107/9/3761    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kiefel, V. Articles by Greinacher, A. Search for Related Content PubMed PubMed Citation Articles by Kiefel, V. Articles by Greinacher, A. Related Collections Hemostasis, Thrombosis, and Vascular Biology Transfusion Medicine Brief Reports Clinical Trials and Observations Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSFUSION MEDICINE Brief report Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT) Volker Kiefel, Dirk Bassler, Hartmut Kroll, Bosco Paes, Günter Giers, Juliana Ditomasso, Heidemarie Alber, Monika Berns, Bea Wiebe, Ernst-Markus Quenzel, Jochen Hoch, and Andreas Greinacher From the Department of Transfusion Medicine, University of Rostock, Germany; Departments of Pediatrics (Neonatology Division) and Transfusion Medicine, McMaster University, Hamilton, ON, Canada; Institute for Clinical Immunology and Transfusion Medicine, University of Giessen, Giessen, Germany; Institute for Transfusion Medicine and Hemostaseology, University of Düsseldorf, Germany; Institute for Transfusion Medicine, German Red Cross Blood Transfusion Service, Dresden, Germany; Department of Neonatology—Otto Heubner Centre, Charité Campus Virchow, Berlin, Germany; Department of Neonatology and Pediatric Intensive Care, Asklepios Clinic, St Augustin, Germany; Department of Transfusion Medicine, Helios Clinic, Schwerin, Germany; Institute for Experimental Hematology and Transfusion Medicine, University of Bonn, Germany; and Institute for Immunology and Transfusion Medicine, University of Greifswald, Germany. Neonatal alloimmune thrombocytopenia (NAIT) is a fetomaternal incompatibility most commonly induced by maternal anti-HPA-1a, IgG alloantibodies against a polymorphic epitope of the glycoprotein IIb/IIIa complex in approximately 97.5% of white patients. Current guidelines recommend transfusion of immunologically compatible platelets to prevent cerebral hemorrhage, the most severe complication in affected newborns. Such platelet concentrates, however, are often not readily available. In a retrospective analysis in German and Canadian centers, 27 newborns with NAIT were identified who received platelets from random donors. Unexpectedly, 24 of 27 newborns showed an increase above a threshold of 40 x 109 platelets per liter, with moderate (n = 8) or significant (n = 16) platelet count increments (more than 80 x 109/L). We conclude that transfusion of platelet concentrates from random donors is an appropriate strategy in the management of unexpected, severe NAIT predominantly in first pregnancies, pending the availability of compatible platelets. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: When are platelets just platelets? James B. Bussel Blood 2006 107: 3426-3427. [Full Text] [PDF] This article has been cited by other articles: M. A. Saxonhouse and M. C. Sola-Visner Thrombocytopenia in the Neonatal Intensive Care Unit NeoReviews, September 1, 2009; 10(9): e435 - e445. [Abstract] [Full Text] [PDF] C. Kaplan Neonatal alloimmune thrombocytopenia Haematologica, June 1, 2008; 93(6): 805 - 807. [Full Text] [PDF] D. Allen, S. Verjee, S. Rees, M. F. Murphy, and D. J. Roberts Platelet transfusion in neonatal alloimmune thrombocytopenia Blood, January 1, 2007; 109(1): 388 - 389. [Full Text] [PDF]

	Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020