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Blood, 15 November 2006, Vol. 108, No. 10, pp. 3335-3343. Prepublished online as a Blood First Edition Paper on August 3, 2006; DOI 10.1182/blood-2006-05-021386. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-05-021386v1 108/10/3335    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nakazawa, F. Articles by Sheng, G. Search for Related Content PubMed PubMed Citation Articles by Nakazawa, F. Articles by Sheng, G. Related Collections Hematopoiesis and Stem Cells Signal Transduction Stem Cells in Hematology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Negative regulation of primitive hematopoiesis by the FGF signaling pathway Fumie Nakazawa, Hiroki Nagai, Masahiro Shin, and Guojun Sheng From the Laboratory for Early Embryogenesis, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan. Hematopoiesis is controlled by multiple signaling molecules during embryonic and postnatal development. The function of the fibroblast growth factor (FGF) pathway in this process is unclear. Here we show that FGF plays a key role in the regulation of primitive hematopoiesis in chicks. Using hemoglobin mRNA expression as a sensitive marker, we demonstrate that timing of blood differentiation can be separated from that of initial mesoderm patterning and subsequent migration. High FGF activity inhibits primitive blood differentiation and promotes endothelial cell fate. Conversely, inhibition of FGFR activity leads to ectopic blood formation and down-regulation of endothelial markers. Expression and functional analyses indicate that FGFR2 is the key receptor mediating these effects. The FGF pathway regulates primitive hematopoiesis by modulating Gata1 expression level and activity. We propose that the FGF pathway mediates repression of globin gene expression and that its removal is essential before terminal differentiation can occur. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Shin, H. Nagai, and G. Sheng Notch mediates Wnt and BMP signals in the early separation of smooth muscle progenitors and blood/endothelial common progenitors Development, February 15, 2009; 136(4): 595 - 603. [Abstract] [Full Text] [PDF] T. Nishimura and M. Takeichi Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling Development, April 15, 2008; 135(8): 1493 - 1502. [Abstract] [Full Text] [PDF] M. Walmsley, D. Cleaver, and R. Patient Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1 expression during embryonic blood development Blood, February 1, 2008; 111(3): 1157 - 1166. [Abstract] [Full Text] [PDF] B. Schiedlmeier, A. C. Santos, A. Ribeiro, N. Moncaut, D. Lesinski, H. Auer, K. Kornacker, W. Ostertag, C. Baum, M. Mallo, et al. HOXB4's road map to stem cell expansion PNAS, October 23, 2007; 104(43): 16952 - 16957. [Abstract] [Full Text] [PDF]

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