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Blood, 15 November 2006, Vol. 108, No. 10, pp. 3573-3579. Prepublished online as a Blood First Edition Paper on July 18, 2006; DOI 10.1182/blood-2006-05-024539. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2006-05-024539v1 108/10/3573    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Vidarsson, G. Articles by van de Winkel, J. G. Search for Related Content PubMed PubMed Citation Articles by Vidarsson, G. Articles by van de Winkel, J. G. Related Collections Immunobiology Phagocytes Free Research Articles Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PHAGOCYTES FcRn: an IgG receptor on phagocytes with a novel role in phagocytosis Gestur Vidarsson, Annette M. Stemerding, Nigel M. Stapleton, Suzanne E. Spliethoff, Hans Janssen, Frank E. Rebers, Masja de Haas, and Jan G. van de Winkel From the Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht; the Laboratory of Vaccine Research, The Netherlands Vaccine Institute, Bilthoven, the Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam; the Eijkman-Winkler Institute, University Medical Center Utrecht; the Division of Cell Biology, Netherlands Cancer Institute, Amsterdam; and Genmab, Utrecht, The Netherlands. Here, we report that the MHC class I-related neonatal Fc receptor (FcRn) is expressed within azurophilic and specific granules of neutrophils and relocates to phagolysosomes on phagocytosis of IgG-opsonized bacteria. We found FcRn to enhance phagocytosis in a pH-dependent manner which was independent of IgG recycling. IgG-opsonized bacteria were inefficiently phagocytosed by neutrophils from 2M knock-out or FcRn -chain knock-out mice, which both lack expression of FcRn. Similarly, low phagocytic activity was also observed with mutated IgG (H435A), which is incapable of binding to FcRn, while retaining normal binding to classical leukocyte Fc receptors. Finally, a TAT peptide representing intracellular endocytosis and transport motifs within FcRn strongly inhibited IgG-mediated phagocytosis. These findings support a novel concept in which FcRn fulfills a major role in IgG-mediated phagocytosis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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