Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 1 December 2006, Vol. 108, No. 12, pp. 3871-3880.
Prepublished online as a Blood First Edition Paper on August 22, 2006; DOI 10.1182/blood-2006-03-014225.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Table
Right arrow All Versions of this Article:
blood-2006-03-014225v1
108/12/3871    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lambert, M.
Right arrow Articles by Caillat-Zucman, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lambert, M.
Right arrow Articles by Caillat-Zucman, S.
Related Collections
Right arrow Immunobiology
Right arrow Clinical Trials and Observations
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

IMMUNOBIOLOGY

Differences in the frequency and function of HHV8-specific CD8 T cells between asymptomatic HHV8 infection and Kaposi sarcoma

Marion Lambert, Monique Gannagé, Alexandre Karras, Michal Abel, Christophe Legendre, Delphine Kerob, Felix Agbalika, Pierre-Marie Girard, Celeste Lebbe, and Sophie Caillat-Zucman

From the Institut National de la Santé et de la Recherche Médicale (INSERM), U561 AVENIR Team, Université Paris 5; Hôpital Foch, Service de Néphrologie, Suresnes; Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital Necker, Service de Transplantation Rénale, Paris; AP-HP, Hôpital St-Louis, Service de Dermatologie, Université Paris 7, INSERM U716; AP-HP, Hôpital St-Louis, Laboratoire de Virologie, Paris; and AP-HP, Hôpital St-Antoine, Service des Maladies Infectieuses, Paris, France.

It is unclear how the immune response controls human herpesvirus 8 (HHV8; also known as Kaposi sarcoma–associated herpesvirus [KSHV]) replication and thereby prevents Kaposi sarcoma (KS). We compared CD8 T-cell responses to HHV8 latent (K12) and lytic (glycoprotein B, ORF6, ORF61, and ORF65) antigens in patients who spontaneously controlled the infection and in patients with posttransplantation, AIDS-related, or classical KS. We found that anti-HHV8 responses were frequent, diverse, and strongly differentiated toward an effector phenotype in patients who controlled the infection. Conversely, HHV8-specific CD8 cells were very rare in patients who progressed to KS, and were not recruited to the tumoral tissue, as visualized by in situ tetramer staining of KS biopsies. Last, HHV8-specific CD8 T cells were observed in a seronegative recipient of an HHV8infected graft who remained persistently aviremic and antibody negative, suggesting that specific cytotoxic T lymphocytes (CTLs) may provide protection from persistent HHV8 infection. These results support the crucial role of cellular immune responses in controlling HHV8 replication, in preventing malignancies in latently infected subjects, and in conferring genuine resistance to persistent infection. They may also have important implications for the design of prophylactic and therapeutic HHV8 vaccines, and for adoptive immunotherapy of KS.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 BloodHome page
A. Guihot, E. Oksenhendler, L. Galicier, A.-G. Marcelin, L. Papagno, A.-S. Bedin, F. Agbalika, N. Dupin, J. Cadranel, B. Autran, et al.
Multicentric Castleman disease is associated with polyfunctional effector memory HHV-8-specific CD8+ T cells
Blood, February 1, 2008; 111(3): 1387 - 1395.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
F. Bihl, M. Narayan, J. V. Chisholm III, L. M. Henry, T. J. Suscovich, E. E. Brown, T. M. Welzel, D. E. Kaufmann, T. M. Zaman, S. Dollard, et al.
Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes
J. Virol., May 1, 2007; 81(9): 4904 - 4908.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020